The most common and widely raised poultry birds are chicken. Since the early 1960s, global per capita consumption of eggs has almost doubled, while poultry meat consumption has increased fivefold. The highest growth has occurred in Asia and Latin America. Between 2000 and 2030, per capita demand for poultry meat is projected to increase by 271 percent in South Asia, 116 percent in Eastern Europe a
nd Central Asia, 97 percent in the Middle East and North Africa and 91 percent in East Asia and the Pacific. Poultry is the world’s primary source of animal protein, followed by pork. Meat and eggs from indigenous poultry differ in appearance and taste from commercial poultry products, and are often preferred by consumers. For example, eggs from indigenous hens are considerably smaller than eggs from commercial layers (usually weighing over 50 percent less) and may have specific qualities. For instance, the Fayoumi breed, originally from Egypt, lays small eggs with a large yolk. Poultry immunity, health, and production are several factors that challenge the future growth of the poultry industry. Consumer confidence, product quality and safety, types of products, and the emergence and re-emergence of diseases will continue to be major challenges to the current situation and the strategic future of the industry. Foodborne and zoonotic diseases are strictly linked with poultry. Eradication, elimination, and/or control of foodborne and zoonotic pathogens present a major challenge to the poultry industry. In addition, the public health hazards from consuming foods with high antibiotic residues will remain a critical issue. The theory of poultry production described in this review will not be limited to considering disease control. Rather, it will also incorporate the interconnection of the animals' health, welfare, and immunity. It is essential to know that chickens are not susceptible to intranasal infection by the SARS-CoV-2 (COVID-19) virus. Nevertheless, the COVID-19 pandemic will affect poultry consumption, transport, and the economics of poultry farming. It will also take into consideration economic, ethical, social dimensions, and the sustenance of the accomplishment of high environmental security. Stockholders, veterinarians, farmers, and all the partners of the chain of poultry production need to be more involved in the current situation and the strategic future of the industry to fulfill human demands and ensure sustainable agriculture. Thus, the present review explores these important tasks. Disease control, high production, product quality, and reasonable production costs have been the recent main goals of the poultry industry. Hence, meeting per capita consumption and welfare to humans necessitates continuous efficient and goal-oriented healthcare to control disease spread and decrease the application of antibiotics (1). These endeavors will include the launch of programs to control infectious diseases, face the constant changes in political and social conditions, address consumers' perceptions about animal welfare, and ensure the safety and security of foods and environmental defense issues. In addition, the continuous increase in the costs of feedstuffs—and thus feeds and foods—remain prominent issues (2). The occurrence of unanticipated and new diseases and new legislation in several countries will also remain essential issues. Food Safety
Consumers' perspectives on the quality and safety of animal products are a continuous issue for the poultry industry and its strategic future (3–5). Many foodborne diseases can be transferred through the food chain. In the available literature, Salmonella serovars and Campylobacter spp. are the poultry bacteria more often responsible for human foodborne diseases. In addition, public health concerns on the development of resistant bacteria due to the abuse of antibiotics as growth promoters and drugs are emerging public health challenges. Controlling zoonotic diseases and foodborne pathogens involves a deep understanding of how microbial pathogens invade and colonize, as well as the circumstances that encourage or stop growth for each strain of organism (2, 5). The Act 2160/2003/EC was passed in November 2003 by the European Council (6) European Commission (EC, 2003) on the prevention of salmonella and other specific foodborne zoonotic agents. This directive and several protocols cover the adoption of targets aimed to decrease the occurrence of specific zoonoses at the level of principal production, in broilers, layers, and turkeys. After approval of the relevant control act, food industry workers must have samples taken and analyzed for zoonotic and zoonoses agents. In addition, a competent authority should sample the flocks. There has been a strong reduction in specific Salmonella serovars, including Salmonella enteritidis and Salmonella typhimurium, due to these orders (7). also contributes to foodborne diseases and represents the principal origin of zoonotic enteric infections throughout the world. Campylobacter infections in humans are primarily transferred via the food chain. There is no proof for either horizontal or vertical transmission from one flock to another with regard to a known poultry house contamination. However, microorganisms can be detected in the gut of killed birds. Hence, the main way for Campylobacter transfer in chickens seems to be the environmental horizontal transmission. The external Campylobacter load per bird is elevated during different slaughter processes, including transport, de-feathering, and evisceration (8). However, there are reductions during other phases of processing, with an overall 4–5 log decrease of the load from production to consumption. Adequate protocols of hygienic control should be used and strictly implemented in all phases of production. Biosecurity should be enhanced throughout the chain of production. Given that Campylobacter spp. can be observed in hygienic barriers, an environment should be built to maintain them far away from the poultry house (9). To guard consumers, the EU approved a unified methodology for the safety of food from the farm to the fork. The approach involves both risk management after risk measurement of assessments, including all key participants, specifically EU Member countries, the European Commission, the European Parliament, the European Food Safety Authority (EFSA), the European Centre for Disease Prevention and Control (ECDC), and economic operators. The methodology is sustained by effective and timely risk communication actions. These endeavors support European decision-makers in implementing decisions and establishing policies to safeguard consumers in the European Union (EU). The World Health Organization (WHO) and the Food and Agriculture Organization (FAO) risk assessment definitions encompass the scientific assessment of potential adverse health and known negative effects. These concepts are vital parts of threat analysis, which comprise risk management, as well as evaluating, selecting, and applying various courses of action. These procedures should be followed by risk communication, which means exchanging information among all concerned parties. The four steps of risk assessment are: (1) documentations of a hazard; (2) assessment of exposure; (3) hazard characterization; and (4) risk characterization (10). The “General Food Law” was established on February 21, 2002 (Regulation EC/178/2002). After a transition period, the law has been enforced since January 1, 2005 (11) to provide a framework for surveilling feeds and the health, welfare, and hygiene of animals. In addition, contaminants and residues, novel food, additives, flavorings, packaging, and irradiation of foods are covered by this law. The food law objectives are to ensure a high level of protection to human life and health, considering animal health and welfare protection, plant health, and the environment. The aims of the several pieces of EU legislation toward food safety were cited (12) as follows. First, consumer health safety is ensured by decreasing the use of medicines/antibiotics, improving resistance to disease, controlling zoonotic pathogens, and ensuring the traceability of animals and their products. Second, product safety is ensured by controlling the hygiene of the processing steps and tracing products and materials anticipated to contact the food. Third, animals should be reared and kept according to existing governmental regulations. Fourth, products and contents are improved via quality and food chain control systems and poultry and poultry-product traceability. Fifth, the tasks serve to reduce environmental contamination. Finally, rural impact, economic effects, and bio-diversity are also considered. Other important issues are consumers' failure to apply proper, hygienic, and acceptable handling and cooking of food, as well as the limited ability of the processing plants to decrease the concentration of pathogenic microorganisms in animal products. Hence, future strategic plans are required to decrease contamination of chickens before their dispatch to processing plants and to ensure there is an adequate focus on the reduction in the availability of feed ingredients for animal feeds in view of the COVID-19 pandemic's effects on the food chain and feed industry around the world. Antibiotic Resistance and Related Problems
Antibiotic tolerance in humans and animals (especially bacteria) is now a common topic, and it is expected to be a continuous public health hazard (12, 13). Fortification of animals' diets with antibiotics to promote growth has increased the public's concern about the safety of animal products and their adverse effects on human health and natural immunity. The impact of antibiotics on the gut flora leads to enhanced digestion and absorption, and, thus, the availability of nutrients for production due to an improved gut ecosystem that favors beneficial microorganisms. Nonetheless, antibiotics can also amplify the occurrence of drug-tolerant bacteria. Considering the precautionary principle and experiences that have been gained in some European countries, antibiotics have been banned as “growth-promoting” for food-producing animals since January 2006. Practical opinions from experience gained in Europe revealed several problems after the ban of antibiotics in poultry nutrition: Growth and feed utilization were impaired, and ammonia level and wet litter were increased with elevated, footpad dermatitis, and thus a general decrease in animal welfare. In addition, health prospects such as enteric disorders due to clostridial infections and dysbacteriosis increased (14). Around the world, multidrug-tolerant bacteria have progressively become a serious risk to animals and, thus, to human health and successful antibacterial treatment. Furthermore, the discovery or production of novel antibiotics does not meet the occurrence of antimicrobial tolerance in bacteria (15). For example, vancomycin-resistant enterococci (VRE) are among the multi-resistant bacteria that have increased nosocomial infections in humans (16). The prevalence of VRE in flocks of turkey raised in southwestern Germany has been investigated. Isolated enterococci were examined for the incidence of the vancomycin tolerance genes—vanA, vanB (B1/B2/B3), and vanC (C1/C2/C3)—using real-time polymerase chain reaction (PCR). VRE was observed in 15 out of 20 (75%) tested turkey flocks. Enterococci bearing van genes were also identified in dust samples (17). Maasjost et al. (18) tested the antimicrobial sensitivity of 145 Enterococcus strains from poultry. Eighty-nine isolates were tolerant to three or more antimicrobial types. Turkey isolates stood out with 42 (81%) multi-tolerant isolates. The most frequent tolerant patterns of Enterococcus faecalis were lincomycin, tetracycline, and gentamicin in all poultry production systems. Recently, coagulase-negative staphylococci (CoNS) were isolated from healthy turkeys in Egypt by Moawad et al. All were phenotypically unaffected by tetracycline, penicillin, sulfamethoxazole/trimethoprim, and ampicillin. The tolerance rats to chloramphenicol, erythromycin, daptomycin, oxacillin, and tigecycline were 94.9, 97.4, 89.7, 92.3, and 87.2%, respectively. Thirty-one (79.5%) were impervious to linezolid. The ermC gene was found in all isolates tolerant to erythromycin, whereas two resistant isolates possessed three resistance-conferring genes: ermA, ermB, and ermC. The cfr and optrA genes were recorded in 11 (35.5%) and 12 (38.7%) of the 31 linezolid-resistant isolates. Besides, livestock-connected with methicillin- resistant Staphylococcus aureus (LA-MRSA) has been found in a number of species of animals and farmers (20–22). Extended-spectrum beta-lactamase (ESBL) bacteria have also been observed in poultry. Richter et al. (23) examined the occurrence of LA-MRSA in turkeys' farms and farmer who reared growing turkeys. Eighteen of 20 (90%) tested flocks were confirmed to have MRSA. On 12 of the farms, 22 of the 59 (37.3%) individuals' tests were shown MRSA. None of them revealed clinical signs suggestive of a MRSA infection. The poultry farmer was expected to be positive for MRSA. Most flocks were positive for MRSA that could be allocated to clonal complex (CC) 398. In five flocks, there was MRSA of spa-type t002 that is not connected to CC398. El-Adawy et al. (24) studied 76 Campylobacter jejuni isolated from the meat of 67 epidemiologically unrelated turkeys from various regions in Germany; only one isolate was sensitive to all examined antibiotics. Of the isolated, 44 (57.9%) were tolerant of amoxicillin, 69 (90.8%) to streptomycin, 61 (80.2%) to erythromycin, and 58 (76.4%) to neomycin. The tolerance to metronidazole, sulfamethoxazole/trimethoprim, nalidixic acid, ciprofloxacin, and tetracycline was 58 (76.3%), 58 (76.3%), 51 (67.1%), 53 (69.7%), and 42 (55.3%), respectively. Multidrug-resistance to three or more groups of antimicrobial substances fluctuated from 3.9 to 40.8%. Another study examined isolates gathered from various flocks of free-range turkeys in Germany (25). It reported similar results with regard to Campylobacter isolates to a Kenyan study that examined chickens reared in backyards and on a small scale (26). Recently, Moawad et al. (27) reported the appearance of colistin-tolerant and extended-spectrum β-lactamase-producing Escherichia coli from healthy broilers in Egypt. In addition, multidrug-resistant E. coli has been reported from cloacal swabs of broiler chickens in Bangladesh (28). There may also be an increase in the use of antibiotics in feed-producing animals during the COVID-19 pandemic to improve animal immunity and health and increase animal farming profits. However, this use may increase the threat of antibiotic-resistant bacteria and the negative impact of antibiotics on the environment, such as cross-resistance and carryover influences. Welfare of Poultry
Currently, there is great concern about the welfare of animals, hygiene, and disease control that may result from great genetic pressure to boost egg and meat production. Indeed, genetic pressure to improve the productive performance of animals adversely affects animals' welfare and natural immunity and thus disease tolerance. However, genetic selection occurs with improved practices of husbandry, disease control, and nutrition manipulation (29). The most achievable alterations have been a decrease in the market age of approximately 4 weeks, a better growth rate, greater breast yield, and a higher laying rate and daily egg mass. However, there is a huge unease that the serious welfare of animals and problems of the disease have already been initiated due to the above-mentioned selection pressure. Increasing selection pressures also hinder animals' freedom (30). Previous studies have indicated that the relationship between the pressures of genetic selection and other meteorological and husbandry factors may negatively affect animals' health status, with an emphasis on the rate of growth and bone and blood supply essential for the development of supporting structures (31). Some birds may be selected that show reduced cardiopulmonary capacity compared to traditional lines and, consequently, impaired heart and lung function. This phenomenon can result in pulmonary hypertension, sudden death syndrome, deep pectoral myopathy, and aortic rupture (32). Furthermore, genetic selection has been most implicated as the major cause of skeletal diseases, which currently draw considerable concentration as a reason for disquiet from an animal welfare point of view. The most common musculoskeletal disorders (footpad dermatitis and dyschondroplasia) are related to fast growth comprises. The incidence and severity of skeletal disorders can be affected by genetic selection and feeding (33, 34). Therefore, it is vital to know the correlation between the pressures of genetic selection and other aspects that may influence the status of animal health and disease tolerance. Based on the literature about the new Strategy for Animal Health in the European Union (2007–2013), the theory of animal health shelters includes a lack of animal diseases and the relationship among the animals' health, welfare, and hygiene. It also considers the economic, social, and ethical concerns, as well as the methods required to accomplish a high level of hygiene and safeguard the environment (31, 35). It is expected that COVID-19 lockdowns will reduce animal welfare due to a shortage of workers for daily animal care and farming, rearing restrictions under free-range and backyard husbandry, and limited access to feeds and disease treatments. The Movement of Poultry and Poultry Products
Strong production competition and cost differences from around the world will affect the cost and global movement of poultry and its products. This phenomenon will increase the possibility of disease transmission into places thought to be free from poultry diseases. However, SARS-CoV-2 is not linked with poultry or its products (36, 37), it will likely influence the global poultry trade due to lockdown and restrictions that is applied to control the spread of the virus. Globally, poultry diseases will continue to be the primary issue for the poultry industry and its strategic future. The outbreak of any disease can turn into an epidemic and have an extensive adverse influence on the global trade of poultry products. Increased feeding cost and raw ingredient prices as well their availability will negatively influence the growth of the industry and consumers' purchasing power, particularly after the COVID-19 pandemic. Moreover, increases in biogas and biofuel production will decrease the land available for grain production and feed for animal productions. This phenomenon will hinder the strategic vision of some counties, such as Saudi Arabia, to achieve their future goals. Specifically, there could be a marked increase in the cost of feeding for animal production and elevated product prices. In the future, the feed industry has an obligation to ensure the quality of feedstuffs and that they are free of pathogens and ecologically friendly. Besides, limited water resources and climatic changes are also expected to adversely affect poultry production costs and strategic planning to meet per capita consumption in areas such as Saudi Arabia (5). Emergence and Re-Emergence of Poultry Diseases
Several factors can hasten and/or prompt the emergence of animal diseases. These factors comprise the development and structure of the poultry farming, amplify global competition and costs of production, and increase the poultry and poultry products movement worldwide. The increased movement could also raise the hazard of introducing infections to specific regions that are free from such diseases (5). Resurgent and re-emerging infections are those that have occurred in the past but are now quickly growing either in a specific geographic area or in the host range. Infectious diseases and health disorders are mostly connected to negative economic impacts. Several pathogens are implicated as potential reasons for poultry diseases, either individually (mono-causal), in synergy with different other microorganisms (multi-causal), or facilitated by non-infectious causes. Non-infectious agents that affect poultry health include weather conditions, hygienic status, house structure and density, water and feed hygiene, and poultry farmers' knowledge and qualifications (31). These aspects influence one another and can stimulate or control the animals' health status. Poultry farmers should provide proper nutrition, a suitable environment, husbandry, and disease control programs to ensure the desired production yield (5). Husbandry must be oriented to meet the standard rearing conditions to support optimal poultry immunity, health, and performance and to avoid disease transmission. Any stress-causing agent can hinder poultry disease resistance, increase the susceptibility of chickens to infections, and decrease the effectiveness of vaccinations. Various infectious pathogens, including bacteria, viruses, parasites, and fungi, contribute to infectious diseases in poultry and can be transmitted and subsequently spread in farms via horizontal and/or vertical transmission (5). Just after hatching, disease transmission is mainly vertical, specifically poor hatching conditions and improper sanitation in the hatchery (omphalitis/yolk sac infection). This transmission can lead to infections with mycoplasma, aspergillus, E. coli, salmonella, pseudomonas, streptococci, staphylococci, encephalomyelitis, and hepatitis. The transmission of different microorganisms, including the above-mentioned one, can also occur through horizontal (lateral) means through direct contact between animals
Avian flu, infectious bronchitis, Newcastle disease, Gumboro, avian metapneumovirus, Ornithobacterium rhinotracheale, E. coli, and mycoplasma are the most common poultry diseases around the world. In Saudi Arabia, the most common poultry diseases are avian flu, Newcastle disease, Gumboro, infectious bronchitis, epidemic tremor-avian encephalomyelitis, infectious laryngotracheitis (ILT), mycoplasma, colibacteriosis, infectious Coryza, and coccidiosis. However, these diseases depend on the hygienic conditions, geographic area, season, metrological factors, and production goals (layers vs. broilers, as well as the breed). The most hazardous disease in Saudi Arabia and many other countries is avian flu, due to a lack of appropriate vaccinations. This disease usually occurs during the winter season, with the start of migrating wild birds crossing Saudi Arabia during their route (38, 39). Enteric disorders that result from infection by rotavirus, coronavirus enteritis, and parasitic infestation problems and E. coli cause substantial losses to the poultry industry. The most recent vital problems of poultry have been respiratory diseases. The severity of clinical signs, duration of disease, and rate of mortality and morbidity are highly variable and affected by virulence, type, and pathogenicity of the infectious agent(s), meteorological conditions, and environmental aspects such as high stocking density, poor management, ventilation, and condition of litter, high levels of toxic gasses such as ammonia and carbon dioxide, hygiene, coexisting diseases, and secondary infections. Animal farming around the world has become one, interconnected unit. Thus, the COVID-19 pandemic has highlighted the need for acknowledging the great risk that current viruses and future microorganisms that may lead to pandemics pose to animal health. Governments should establish new regulations for animal health care, trade, and movements of domestic and wild animals and provide adequate research funds for these activities to establish a strategic plan to ensure a continuous supply of animal protein. The Challenges From the SARS-CoV-2 (COVID-19) Virus
SARS-CoV-2 has emerged as systemic a zoonotic disease that poses serious hazards to humans. The Betacoronavirus group includes COVID-19, SARS-CoV, and MERS-CoV. SARS-CoV-2 is an enveloped virus that is highly infectious, even though it is easily destroyed by soap and common disinfectants. Coronaviruses are divided into alpha, beta, gamma, and delta groups. A wide range of emerging and existing diseases in food-producing animals are caused by coronaviruses (37). Various poultry body functions and systems—hepatic, renal, respiratory, neurological, and enteric—are adversely affected by coronaviruses, such as infectious bronchitis. A prevention strategy to control the spread of COVID-19 is a lockdown, blocking transmission pathways, and educating the public to increase their awareness of the disease and decrease trade activities (40). Based on the literature, COVID-19 transmission can be impacted by some metrological factors, droplets, the population density, and direct-indirect interaction. Nevertheless, further research is required. In order to control the recent outbreak, a global strategy must be developed and applied worldwide. The lessons that have been learned from COVID-19 are myriad and cannot be easily enumerated. However, perhaps the most important lessons are the need to boost natural immunity as the first line of defense and that the health of the world must be considered as one unit that cannot easily be disentangled. It will take time to develop an effective vaccine that can be a permanent solution, and/or specific antiviral therapy for SARS-CoV-2 (40, 41). In addition, Rahman et al. (41) called for increasing diagnostic facilities, diagnostic kits, trained physicians, and a sufficient number of hospital beds. In addition, the general public must be aware of SARS-CoV-2 to control the outbreak or break the infection cycle. In 2019, the weakness of the health system was highlighted due to an insufficient number of hospital beds, lack of adequate diagnostic kits, inadequately trained physicians, and a large number of deaths, including health professionals, physicians, nurses, and health care workers. The world must put more effort into the development of medical education, health care programs, fighting poverty, and feeding the hungry. With limited knowledge about the COVID-19 pandemic and our increasingly interconnected and multifaceted world, what is ultimately and necessarily required are robustness, flexibility, and pliability to deal with unforeseen future situations and dialogues (42). With regard to the poultry industry, great attention has been given to restrict avian infectious bronchitis virus (IBV), which is part of the genus Gammacoronavirus and not transmitted to humans (37, 43, 44). Given that SARS-CoV and COVID-19 are from the same genus and use the same angiotensin-converting enzyme 2 (ACE2) host cell receptor, SARS-CoV does not infect or cause disease in poultry (39). This fact suggests that poultry is unlikely to disseminate or serve a reservoir for these viruses (36, 43). IBV induces an acute, highly contagious infectious disease of chickens (44). IBV is globally distributed and responsible for huge economic losses in the poultry industry. Initially, the virus infects the respiratory system; however, some strains show a shift in tissue tropism and spread to other organs, such as the kidneys, oviduct, and proventriculus (45, 46). The infection is mostly accompanied by a reduction in the growth rate and a drop in egg quality and quantity (47–49). As of June 23, 2020, the mortality rate for all COVID-19 cases was 5.2% (total deaths/total confirmed cases; https://www.nsbstat.com/1/covid), which is much lower than SARS (9.6%), and far from MERS (34%), and Ebola virus (65.7%). Virus transmission is influenced by many factors, including density and movement of the population, and weather conditions such as humidity and temperature. Although the similarity in the genetic make-up of humans and chickens is about 60%, the immune system of humans and avian species is very different, and thus vaccinations protocol, types, and applications are different. The production of human vaccines is essential to save lives and ensure the wellbeing and, hence, much more important than the production of a vaccine for farm animals. Poultry production does not seem to be at risk due to the global spread of SARS-CoV (37). Nonetheless, increasing biosecurity and hygienic measurements at the farm become apparently vital and need further efforts to limit the spread of SARS-CoV to the poultry industry and its possible mutation (50, 51). However, very limited research has been performed with the COVID-19 virus in poultry. Jackwood (37) and Swayne et al. (42) have suggested that COVID-19 is not associated with poultry or poultry products. Furthermore, recent unpublished results from the Friedrich-Loeffler-Institut [(Germany; Balkema-Buschmann et al. (36)] have shown that pigs and chickens are not susceptible to intranasal infection by SARS-CoV-2. All swab samples, as well as organ samples and contact animals, remained negative for SARS-CoV-2 RNA, while fruit bats and ferrets infected by the same route simultaneously exhibited the contrary influences which stronger in ferrets than fruit bats (Personal communication)
Disease Diagnosis
The diagnosis and treatment of poultry diseases are the most common tools to control and prevent disease transmission and spread (44, 45, 52). The most recent example is avian influenza, where early diagnosis of the source and route of virus spread helped to control the disease and develop an effective vaccine for this zoonotic disease (44, 53). In a future study, improvements in laboratory diagnosis will offer sensitive, fast, and precise disease diagnosis, and early mediations will be a reality (45–47). Furthermore, vaccines developed for IBD and IBV, and early for Newcastle disease virus (NDV) and coccidiosis, have helped to save billions of dollars to the industry, as well as improve industry safety and protect it from disease outbreaks (54, 55). A major lesson from the COVID-19 pandemic is that world health is one unit. Thus, developing fast, accurate, and affordable diagenetic tools/kits that can be used on farms is absolutely necessary, and research in this area should be initiated and given maximum funding and impetus. Treatment
For a long time, treatment of poultry diseases has been a very successful strategy for disease control, eradication, and prevention. Good examples include bacterial, fungal, and parasitic diseases such as cholera, aflatoxin, and coccidiosis (44). Treatment of poultry diseases has allowed increased investment in the poultry industry in many developing countries that suffer from low hygiene and biosecurity (54, 55). These investments have improved and will continue to improve human welfare, fight poverty, increase family income, and ensure food security at affordable prices (2). In the future, a few authorized pharmaceuticals and veterinary products will be available to treat poultry as food-producing animals (53). Prospective research on the mechanisms of pathogenic bacteria will precisely diagnose bacterial infections, and therapy will help develop new drugs/tools that can eliminate the adverse properties of pathogens on animal's health and productivity (55). Treatment protocols for zoonotic disease and their associated secondary infections, as well as alternative protocols, should be developed after the COVID-19 pandemic. Disease Control
The first line of infectious disease control is to prevent the introduction of disease and to prevent further spread via strict biosecurity, establishing and maintaining immunity, and vaccination. Global poultry farming has aggressively selected for traits that focus on maximum poultry production and improving feed utilization and farming profits. Disease control is the key element for improving animal production and food safety and, thus, human well-being. In Saudi Arabia, the National Transformation Program 2020 of the Ministry of Environment, Water and Agriculture, which is a part of the Kingdom 2030 vision, includes the following initiatives to improve animal production and to control the disease:
1. Increase the self-sufficiency ratio of broiler chickens by 42–60%;
2. Monitor infectious diseases to increase the number of animal diseases under control from 2 to 21, especially the most important and widespread diseases in the Kingdom;
3. Increase animal coverage by veterinary services from 20 to 70% to improve productivity and reduce the risk of disease and animal loss due to the cost of treatment, increased mortality, and lack of productivity;
4. Develop veterinary vaccines and production centers for local pathogenic strains;
5. Establish a program to investigate and control of infectious animal diseases. These initiatives will hopefully succeed and positively impact animal production in Saudi Arabia to ultimately improve human wellbeing, boost self-sufficiency, and create new jobs for the younger population. The COVID-19 pandemic has adversely impacted poultry meat production: There has been a 2% decrease in production and a 1% reduction in the global chicken meat trade in 2020 (3). These decreases may be due to lockdowns and fluctuations in global poultry supplies, feeds, shipments, meat, and eggs. The COVID-19 pandemic has highlighted the importance of poultry as a strategic, affordable animal protein. More countries must be able to achieve self-sufficiency in production, an endeavor that requires increased investment after the COVID-19 pandemic ends. Chicken meat production is expected to be decreased during the pandemic as an affordable animal protein supply that is globally accepted (4). In addition, eggs are one of the most affordable protein sources and among the most nutritious. There has been an increase in egg and poultry meat consumption during lockdowns due to several factors, such as low prices, easy and fast preparation, and high nutritional value (3, 4). Compared to the countries with the highest meat and egg production countries, Saudi Arabia imports most of the broiler meat its citizens consume, with production accounting for less than 58% of the consumed meat (4). By contrast, it produces 17% more eggs than its needs (3). Saudi Arabia is also among the top countries in poultry meat and egg consumption. Both eggs and meat are strategic goods; thus, extended the investment in the poultry industry in Saudi Arabia is a promising agricultural sector.