
22/02/2023
Camelpox is an extremely infectious skin disorder and the most common infectious viral illness of camels, occurring in most regions where camel farming is common. The camelpox virus (CMLV; genus Orthopoxvirus, family Poxviridae), the cause of this infectious disease, is closely related to the variola virus. The genes associated with viral replication activities and most of those important in additional host-related processes are identical in the two viruses
Symptoms of camelpox are fever, skin lesions, and lymph node inflammation. Pox lesions of different stages may form, most notably on the face, throat, and near the tail. The disease may be diagnosed based on clinical symptoms, although camel contagious ecthyma and camel papillomatosis induce similar symptoms . Multiple diagnostic methods are available, including transmission electron microscopy (TEM), the most rapid diagnostic tool for detecting the characteristic, brick-shaped orthopoxvirus in tissue samples or skin lesions . Immunohistochemistry can also be informative. PCR may be used to confirm the presence of viral nucleic acid, and DNA restriction enzyme testing can be used to identify specific strains of the CMLV
Prevention and control The infection, like smallpox in humans, may be controlled by separating diseased camels and injecting the remainder with the standard vaccinia virus vaccine or the recently developed CMLV vaccine, available live attenuated and inactivated. A booster vaccine dose is recommended for young camelids inoculated before 6–9 months. The inactivated vaccine can be injected yearly , and the live attenuated vaccine provides long-term protection.
A live attenuated candidate vaccine was produced in Sudan using a local strain of CMLV and assessed in a small-scale field study for safety and efficacy in experimental camels . Most tests revealed that the proposed vaccine is effective, safe, and can control the infection. Most vaccines are produced from the CMLV strains Ducapox 298/89, Jouf-78, VD47/25, and CMLV-T8. The attenuated Jouf-78 strain has been found to provide complete protection against CMLV (17). A new vaccine developed from serial multiplication of the KM-40 virus strain on the chorioallantoic membranes of 11-day-old embryonated chicken eggs has the potential to protect against camelpox in Old World camelids (Camelus dromedaries and Camelus bactrianus)
Treatment General non-specific treatment for infected camels is the administration of 10 mg/kg oxytetracycline and 0.2 mg/kg meloxicam for 5 days . A spray containing gamma benzene hexachloride, proflavine hemisulphate, cetrimide, eucalyptus oil, turpentine oil, and neem oil can also be used for wound therapy and fly control . Other ethnopharmacological applications are also widely used to treat camelpox . In humans, cidofovir would likely be beneficial in the treatment and short-term prevention of smallpox and kindred poxvirus infections, as well as the treatment of vaccinia sequelae in immunocompromised individuals Cidovir and its acyclic nucleoside phosphonate derivatives have shown promising therapeutic potency against camelpox