28/02/2024
Info to keep so i dont forget the actual names - Chemical coccidiostats. Currently, eleven coccidiostats, mainly synthetic chemicals and ionophores, are approved in the EU. Synthetic chemicals influence parasite metabolism by blocking their physiological processes. Halofuginone, robenidine, diclazuril, decoquinate, nicarbazin, toltrazuril, clopidol, ethopabate, amprolium, sulfadimethoxine, and sulfaquinoxaline are some examples. Compounds of this type operate by interfering with one or more stages of the parasite life cycle. They have an effect against its intestinal phases as soon as it attacks the host gastrointestinal system, being potentially more effective in the case of serious infections, but over time, resistance may appear.
Ionophores coccidiostats Ionophores do not exert so much selective pressure on the parasite. Furthermore, this mode of action is oriented towards sporozoites (the developmental stage of the parasite in the intestinal epithelium before host cell pe*******on), and does not result in the complete elimination of the parasite. Instead, they allow low numbers of the parasite to survive and cause the host to acquire immunity. Currently, six ionophore anticoccidials are widely utilized: lasalocid, maduramicin, salinomycin, monensin, narasin, and semduramicin.