04/11/2024
Degenerative myelopathy (DM)
Also known as Chronic Degenerative Radiculmyelopathy (CDRM) is a disease that affects the spinal cord resulting in a slow progressive hind limb weakness and paralysis.
DM is a genetic abnormality, it's an inherited neurological disease that generally affects dogs 8 years and older.
DM causes gradual muscle wastage and incoordination of the hind limbs which progresses to paralysis of the hind limbs. The muscle wastage can also extend to the forelimbs as the disease progresses.
Certain breeds of dogs are more predisposed to DM such as German shepherds, Boxers, Pembroke Welsh corgis and Bernese mountain dogs.
Clinical signs of DM
- Difficulty rising
- Hind limb weakness
- Incoordination
- Muscle atrophy (wastage)
- Scuffed hind limb nails
They're are no specific tests to reveal DM but you can have neurology exams, MRI, CT scans, blood work and spinal fluid analysis to rule anything else out.
Genetic testing can reveal if the dog has one or two copies of the variants associated with the development of DM.
Treatment
Unfortunately there's no cure for DM and it's about managing the condition such as
- Physical therapy to help slow clinical progression and help maintain muscle mass
- Maintain a healthy weight
- Using rugs, non slip mats on slippery floors at home
- Adding pet ramps and steps where required
- Wearing booties to decrease damage to paws
- Using a sling and harness to assist with support and walking
- Considering the use of a wheelchair
- Addressing factors such as arthritis that can contribute to mobility issues
Degenerative myelopathy isn't curable. DM in most breeds are caused by a mutation of the gene SOD1 (SOD1A Variant).
Dogs with two copies are at a higher risk of developing the disease but it doesn't mean they will. A dog that's a carrier (possessing one copy of the gene) may still have a risk of developing DM but the progression is slower that those with two copies of the gene.
Photo Animal ortho care