The Pathology Explorer

19/05/2024

Which ONE of the following IHC markers IS typically used to identify the cell origin of Feline Progressive Histiocytosis (FPH)? CD20 CD1a CD4 E-cadherin Which ONE of the following IHC markers IS reported having a LOW sensitivity when diagnosing an Amelanotic Melanoma in dogs? Melan A PNL-2 HMB45 Tyrosinase-related proteins 1 Which ONE of the following statements on Survivin in canine perivascular wall tumors…...

Which ONE of the following IHC markers IS typically used to identify the cell origin of Feline Progressive Histiocytosis (FPH)? CD20 CD1a CD4 E-cadherin Which ONE of the following IHC markers IS re…

02/05/2024

By Giuseppe Giglia DVM, Ph.D., DECVP Ciao Everyone, and welcome back for a new post! This contains a basic guide that aims to shed a little light on the differential diagnoses of nodular lesions, providing an overview that can serve as a valuable resource for vet professionals and students. Starting with the basics, a nodule can be defined as a…...

By Giuseppe Giglia DVM, Ph.D., DECVP Ciao Everyone, and welcome back for a new post! This contains a basic guide that aims to shed a little light on the differential diagnoses of nodular lesions, p…

07/01/2024

Ciao everyone,

⚠️ Last call! ⚠️ The survey data collection on the perception of diagnostic confidence for modifying phrases used in veterinary pathology reports will remain open for the next 3 weeks (until the end of January).

Please consider participating if you are a veterinarian and you have not done so already! Your expertise is invaluable in shaping insights that make a difference.

In particular, calling all Board-Certified Veterinary Oncologists! We need your opinion on this!

Survey link: https://docs.google.com/forms/d/e/1FAIpQLScFRIpnnuxGJtglrpBM-fkeSsUSAdqrzUJDOU9a8ArzVmILYw/viewform

📊🐶

29/12/2023

Ciao Everyone,

It is now out our last post of 2023!

As it was one of the major emerging infections of this year, I took this opportunity to discuss .

Click the link and enjoy the reading!📑🔝

Ciao Everyone! and welcome back for our last post of these 2023! Has it was one of the major emerging infections of this year, with cases still continuously appearing, I will take this time to disc…

23/12/2023

Ciao Everyone,

a new post is finally out on the blog!

This time we talk about Upper Respiratory Tract Disease (URTD) in ‼️

Enjoy the reading!📑🔝
Click the blog's link in the bio!

Dr. Giuseppe Giglia DVM, Ph.D., DECVP Ciao everyone and welcome back in the blog for this new post! As December brought is some very cold weather 🥶, and everyone around us is starting to sneeze, ou…

21/12/2023

Ciao Everyone,

a new post is finally out on the blog!

This time we talk about the types and tasks of my favourite cells: MACROPHAGES‼️

Enjoy the reading!📑🔝
Click the blog's link in the bio!

Macrophages are a crucial component of the mononuclear phagocyte system (MPS)(previously known as reticuloendothelial system). The MPS comprise a group of cells that involves: monocytes (circulatin…

15/12/2023

Step into the world of , my personal blog where we discuss and ! 🔬

Posts contents span from classic and well-known conditions to the newest knowledge from research papers. Join the conversation, is more fun together!

Click the link 😉 https://thepathologyexplorer.wordpress.com/

09/12/2023

⚠️ NEW POST OUT NOW ⚠️

The skin is the body’s largest organ; it protects the organism from outside stimuli. It is, for this reason, exposed continuously to potential harmful incitements. As any other organ does, th…

03/12/2023

Re-posted •
Ciao Everyone,

A new post is finally out on the blog!

This time we talk about extrarenal lesions of the Uremic Syndrome in ‼️ 🐶

Enjoy the reading!📑🔝
Click the blog's link in the bio!

03/12/2023

Ciao Everyone,

A new post is finally out on the blog!

This time we talk about extrarenal lesions of the Uremic Syndrome in ‼️ 🐶

Enjoy the reading!📑🔝
Click the link: https://wp.me/peWCIz-vD

03/12/2023

Ciao Everyone,
A new post is out now on the blog!

This time we talk about extrarenal lesions of the Uremic Syndrome in ‼️

Enjoy the reading!📑🔝
Click the link below!

Dr. Giuseppe Giglia DVM, Ph.D., DECVP In dogs affected by Uremic Syndrome (US), the intricate interplay of factors associated with Chronic Kidney Disease (CKD) leads to a cascade of detrimental eff…

23/11/2023

A new post is out now on the !

Which one of the following antigens is a marker for endothelial cells? CD3 CD20 CD34 CK7 Which one of the following immunohistochemistry panels is diagnostic for the gastrointestinal stromal tumour…

06/11/2023

⚠️ NEW BLOG's POST ⚠️

Ciao Everyone,

Are you vet path residents, pathologists, or general practitioners?! Well, you do not want to miss this!! A new post is out now on the blog!
This time we talk about 👌🏻🔝📑

Showing us a simple and comprehensive approach to mammary tumors classification and grading is our new guest expert, Dr. Guillermo Valdivia DVM, MSc, Ph.D., DECVP.

Enjoy the reading!📑🔝

Link to the blog in bio!

Guest-Expert Post By Dr. Guillermo Valdivia DVM, MSc, Ph.D, DECVP Canine Mammary Tumors (CMTs) represent 50-70% of all tumors in non-spayed female dogs, with a higher prevalence observed in countri…

31/10/2023

Ciao Everyone,

A new post is out now on the blog!
This time we talk about the term 🦷‼️

Enjoy the reading!📑🔝

Link to the blog in bio !

The term “Epulis” is derived from Greek ἐπί, «on top of» e οὖλον, «gingiva», literally meaning “on the gum”. It is a non-specific term that designates the growth of a tumor-like mass (n…

28/10/2023

‼️NEW POST‼️

Ciao Everyone,

A new post is out now on the blog!
This time we talk about 🔬📑🐕

Enjoy the reading!📑🔝

Link to the blog in bio!

Dr. Giuseppe Giglia DVM, Ph.D., DECVP Infectious canine hepatitis (ICH) is a common, contagious, and life-threatening disease of dogs. It is caused by canine adenovirus 1 (CAV-1). It is transmitted…

25/10/2023

‼️NEW POST‼️

Ciao Everyone,

A new post is out now on the blog!
This time we talk about 🙀

Enjoy the reading!📑🔝

Link to the post below!

Feline acne is a common dermatological disease described in our feline companions. It manifests as keratin-filled and cystically dilated hair follicles (comedones) with subsequent rupture and infla…

17/10/2023

Ciao Everyone!!!

Have you seen our latest posts on the blog ??

Here is a quick !

(1) Feline Immunodeficiency Virus (FIV) and Human Immunodeficiency Virus (HIV): a vet pathologist perspective.
https://thepathologyexplorer.wordpress.com/2023/10/11/feline-immunodeficiency-virus-fiv-and-human-immunodeficiency-virus-hiv-a-vet-pathologist-perspective/

(2) The Devastating Impact of African Swine Fever (ASF): Unveiling the Pathology through macroscopic and histologic lesions description.
https://thepathologyexplorer.wordpress.com/2023/10/02/the-devastating-impact-of-african-swine-fever-asf-unveiling-the-pathology-through-macroscopic-and-histologic-lesions-description/

(3) Hemangiosarcoma in Dogs: Predisposed Breeds, Affected Organs, and Histological Features.
https://thepathologyexplorer.wordpress.com/2023/09/27/hemangiosarcoma-in-dogs-predisposing-breeds-affected-organs-and-histological-features/

(4) Lymphoma in domestic animals: a pathology primer.
https://thepathologyexplorer.wordpress.com/2023/09/13/lymphoma-in-domestic-animals-a-pathology-primer/

12/10/2023

🔗 Link: https://wp.me/peWCIz-re

11/10/2023

‼️ Ciao Everyone ‼️

The new post on similarities and differences of the ( ) and the ( ) is out now on the blog 'The Pathology Explorer.' 🕵️‍♂️🔬

Enjoy the reading 📑🔝

Click the link below‼️

Dr. Giuseppe Giglia DVM, Ph.D., DECVP Feline Immunodeficiency Virus (FIV) is a significant health concern for our feline friends. Similarly to Human Immunodeficiency Virus (HIV), FIV attacks the im…

08/10/2023

Re-posted • - 🔪-



In the picture is a multifocal inflammatory process characterized by a moderate number of , and occasional cells with up to 6 nuclei, with haphazard or horse-shoe shape arrangement ( body and type multinucleated giant cells) surrounding fragments of anisotropic . The same material is also visible in the of the latter cell type.

08/10/2023

Re-posted • - 🐈🧠 -

𝕄𝕖𝕟𝕚𝕟𝕘𝕚𝕠𝕞𝕒
(Fibrous histotype)

This arises from of the .

It is the most common intracranial tumor in and .

Histologically, it can have a variable appearance of diffent patterns. The fibrous histotype is characterized by of elongated cells mixed in extracellular . Cells have indistinct cell borders, moderate amount of eosinophilic and oval with variably dispersed .

08/10/2023

Re-posted • - ☄ -

Tissue from a 🐕

ℙ𝕝𝕒𝕤𝕞𝕒𝕔𝕪𝕥𝕠𝕞𝕒

Predisposed anatomical sites are: , , and

Histologically, this tumor is recognized by proliferating arranged in sheets and cords. Cells are round, generally with well defined cell borders, a moderate amount of eosinophilic cytoplasm with a paler perinuclear zone ( ). The  is round or crescentic. Classic is the chromatin “ ” pattern.

Additionally, intratumoral deposition can be detected (AL amyloid, containing λ light chains or κ light chains).

Plasmacytic tumors are divided into:
▪️Extramedullary
▪️Solitary osseous plasmacytoma
▪️

03/10/2023

Re-Posted •

- Big guys 👾-

(STS)

Histology: Neoplastic spindle arranged into interlacing streams and whorls. Cells have poorly defined cell borders, moderate amount of eosinophilic to light basophilic and oval central with variable pattern and one or multiple nucleoli. Bi and are sometimes common.

The term STS encompasses a big and heterogeneous group of tumors grouped together based on and and similarities.

These include:
▪️Peripheral nerve sheath tumor
▪️Perivascular wall tumor
▪️Fibrosarcoma
▪️Myxosarcoma
▪️Liposarcoma
▪️Pleomorphic sarcoma
▪️Malignant mesenchymoma
▪️Undifferentiated sarcoma

03/10/2023

Re-Posted

- Like 💎 -

from a 🐎

𝙸𝚗𝚝𝚒𝚖𝚊𝚕 𝚋𝚘𝚍𝚒𝚎𝚜

Morphologically recognized as basophilic, oval to star-shaped refractile , representing foci of within the of small sized to medium submucosal

It is an (no clinical significance) and no causes have currently been associated with it.

They are thought to arise from the of subendothelial

02/10/2023

Re-Posted

The 😇 and the 😈

Pictures 1 & 2 are of an , a benign tumor of endothelium.

Pictures 3 & 4 are of an Hemangiosarcoma (HSA), a malignant of vascular .

Histologically, both are composed of blood-filled vascular channels, lined by cells organised in a monolayer. Cells are flat and spindle in the Hemangioma and spindle and plump, bulging into the vascular channel lumens, in the

Anisocytosis and anisokaryosis are mild in the Hemangioma and marked in the Hemangiosarcoma.

are commonly absent in the Hemangioma and numerous in the Hemangiosarcoma.

Immunohistochemical markers for evidence of vascular origin of neoplastic cells are: , ,

The Hemangioma lacks in and potential.

The HSA has different aggressiveness and metastatic potential depending on the site of origin. From highly aggressive and high metastatic potential to low aggressiveness and low metastaticpotential: Visceral HSA > Subcutaneous > Cutaneous (dermis)

Occurrence in sparsely haired and lightly pigmented skin suggests chronic as a factor working as tumor initiator and promoter.

02/10/2023

‼️ Ciao Everyone ‼️

The new post on 🐷 is out now on the blog 'The Pathology Explorer.' 🕵️‍♂️🔬
Enjoy the reading 📑🔝

Click the link below‼️
https://thepathologyexplorer.wordpress.com/2023/10/02/the-devastating-impact-of-african-swine-fever-asf-unveiling-the-pathology-through-macroscopic-and-histologic-lesions-description/

By Giuseppe Giglia DVM, Ph.D., DECVP African Swine Fever (ASF) is a highly contagious viral disease that affects domestic pigs. ASF is currently a growing threat to the global swine industry, causi…

27/09/2023

‼️ Ciao Everyone ‼️

The new post on is out now.

In this article, we will delve into the predisposing factors, affected organs, and macroscopic, histologic, and immunohistochemical features of hemangiosarcomas in .

Enjoy the reading!!

Dr. Giuseppe Giglia DVM, Ph.D., DECVP Hemangiosarcoma, is a malignant and relatively common (5-7% of all malignancies) mesenchymal neoplasm of dogs that has often poor prognosis and fatal outcome. …

20/09/2023

‼️Ciao Everyone‼️

The new test of the series is .

This time is an histological picture of an oral cavity from a Pigeon (Columba livia)

Can you guess the agent❓

Click the link 🔗 below:
https://wp.me/peWCIz-sL

Histological picture; oral cavity from a Pigeon (Columba livia): Figure 1. Oral cavity (x400) from a Pigeon (Columba livia). Numerous heterophils mixed with abundant cell debris and cells with hype…

13/09/2023

Ciao Everyone‼️

Interested in in ❓

Our latest post is now out on the blog ‼️
It is on in 🌟🔬

🧬💡Don't miss it out! Click the below.

Dr. Giuseppe Giglia DVM, Ph.D., DECVP The term Lymphoma (also known as lymphosarcoma) describes a diverse group of malignancies arising from lymphocytes or their precursors in peripheral lymphoid t…