07/06/2022
Is your cat on Lantus? If so, that’s a depot insulin. It’s important to understand some things about this in regards to dose adjustments.
Lantus thrives on consistency in dosing and timing. There’s a big difference in humans using Lantus and cats using Lantus. A cat's metabolism runs about twice as fast as a human. Lantus is one 24 hour shot for humans but a 12 hour shot for cats.
When injected, it creates small crystals in the fatty layer that slowly 'melt' over 2 to 3 days. Very little of any shot is actually 'used' during the cycle it's given. Each time a shot is given, the same small crystals are created and melt over that 2 to 3 days - this is the 'depot' or 'shed'. As seen by that explanation, it will take approximately 3 days to fill the depot.
Each time a dose is changed either up or down, the liver has to find a new 'balance' to use the available insulin.
So why is this important when we hold a new dose for a week or so?
The 'hold' period and the depot fill are separate things even though they're happening at the same time. The 7 to 10 day hold is to allow just a bit of time for the body to adjust to the new amount or, in the beginning, even just having insulin available again.
Some cats take longer to settle into a new dose. I found with Milly, it was around two weeks.
Patience is key - grit your teeth and ride out those wonky numbers following a dose change; get lots of mid cycle testing in and it’ll paint the picture of what’s going on.