11/09/2022
We have gotten a lot of questions about Bute-Less lately… And WE ARE NOT FANS! Here are a few facts that we would like to share with you before you pick up this product or others that contain Devil’s Claw for your horse.
- The primary active ingredient in Bute-Less is the herb Devil’s Claw which contains harpogoside.
- Harpagoside has been shown to have anti-inflammatory effects in people. There are no studies of this effect occurring in horses.
- Devil’s Claw is metabolized in the liver using the enzyme cytochrome p450. While this enzyme is breaking down Devil’s Claw, it cannot breakdown other medications down well. This can lead to accumulation of those medications in the bloodstream and toxicity.
- Devil’s Claw can be nephrotoxic by inhibiting processes for filtration, secretion and absorption in the kidneys.
- Devil’s Claw has been shown to be associated with the development of bleeding gastric ulcers and other severe GI disorders.
- There are no long term use safety studies of this herb.
What this means to you as a horse owner:
Administering any drug to a horse that is being given Devil’s Claw increases the risks and side effects of that drug. For example:
- Administering Banamine to a horse with colic who is being given Devil’s Claw may cause liver failure.
- Administering Gentamicin, an important and common antibiotic used to treat a variety of infections in horses, to a horse being given Devil’s Claw may cause kidney failure.
Plus,
- Harpagoside is a FEI controlled substance
- Devil’s Claw is a USEF prohibited substance
- Horses are already quite efficient at getting gastric ulcers… why add one more risk factor?!
If you have questions about your own horse and Devil’s Claw OR finding other anti-inflammatory options for your horse, please contact your horse’s primary veterinarian at Iron Horse Equine.
Addendum: References reviewed for this post are listed in comments. Absorbine the maker of Bute-Less has commented on our post as well and we recommend that you review their comments and contact them directly regarding Bute-Less specifically. We will be turning off comments on this post at this time and recommend that you reach out to your equine veterinarian for questions and concerns specific to your horse.