Spensers kampanje

14/10/2024

Listene over hunder som bærer Normalgenet N i Norge og Sverige er nylig oppdatert. Gå til siden Genetikkprosjektet for oppdatert liste.

17/09/2024

Gentesting - oppdaterte resultater
Nye N/CDDY hunder:
2 dachshund korthår
8 dachshund langhår
3 dverg/kanindachshund langhår
5 dachshund strihår
Nye N/N hunder:
1 dachshund korthår

Vi minner om muligheten for å teste gjennom bevegelig gentesting, se NDFs hjemmeside.

04/09/2024

SLIK NEDARVES N-GENET
Ved å øke forekomsten av Normalgenet N på kromosom 12 vil dachshundpopulasjonen etter hvert få en bedre rygghelse.

Illustrasjonen viser hvordan ulike foreldrepar vil nedarve N-genet til avkommet.

Dette er slik resultatet blir statistisk sett, men som alle også vet skal et kull statistisk sett bestå av 50:50 tisper og hanner - men at det ikke alltid blir slik ☺

Grønn hund er N/N, Blå er N/CDDY og Gul er CDDY/CDDY

Målet er å først øke andelen blå hunder - samtidig som man tar vare på andre viktige gener i populasjonen. At det også kommer grønne hunder ut av krysningene er bonus.

18/08/2024

The Kennel Club are planning to introduce a ‘breed health standard’ which outlines tests for breeders to undertake, specific to each breed.
The club has emailed its members - if you haven’t received this please check
your junk mail or let us know .

We have set up and easy to use survey to gather your comments here:

https://forms.office.com/e/vETEt6Dmp7

Please will you complete this by 31 August, if you have an opinion and/or comments, your Club will then pass the information to the Kennel Club. We can also include a summary in our newsletter.

With best wishes
Jeff Horswell
President, The Dachshund Club

Information from the Kennel Club:

At present the only formal guidance we give on breed specific health testing is via our Assured Breeders Scheme’s recommendations and requirements. This process has been reviewed during the development of the Health Standard, which will replace this existing Assured Breeders Scheme guidance. The Health Standard will give clear direction to all breeders registering puppies with The Kennel Club, at all levels of experience, and is a crucial step in The Kennel Club achieving the strategic aim to safeguard the future of pedigree dogs by addressing breed-associated health issues.

The Health Standard promotes breed-specific health testing and is a clear evidence-based guide for breeders, of all levels of experience, about health testing priorities within their breed. It represents a crucial step towards The Kennel Club’s strategic aim to safeguard the future health and well-being of pedigree dogs.

The Health Standard uses a consistent and rigorous process to prioritise and categorise health tests based on scientific evidence collated from The Kennel Club’s Breed Health & Conservation Plans (BHCPs). The standard takes into account published literature, prevalence data and – in a first - genetic diversity, in order to categorise and prioritise health tests within every Kennel Club registered breed.

Within the Health Standard, whilst we strongly encourage breeders to undertake all the health tests listed for their breed, each test has been categorised into ‘essential’, ‘advisable’, or ‘other’. This breed-centric categorisation reflects the priority of the tests for the entire breed. These categories highlight which are the most important tests puppy buyers should be looking for and to advise breeders how to prioritise tests when making breeding decisions.



Here’s a brief overview of each category:



Essential tests: These are tests that breeders are strongly encouraged to undertake prior to breeding, as there is strong evidence that the condition being tested for is a significant concern in the breed, for example, it may be increasing in prevalence. Essential tests are not mandatory for registration but have been termed as such to strongly signal the importance of these tests.


Advisable tests: These tests are that breeders should consider to be of importance and are advisable to use prior to breeding – being for conditions which are still known and relevant in a breed. However, they have been categorised as advisable either due to having a lower prevalence than those in the essential category, or due to other considerations within the breed, including the need to balance health test results against genetic diversity.


Other tests: We don’t yet have sufficient data to assess the importance of these tests, however breeders/ puppy buyers should be aware of them and check their lines before breeding or purchasing a puppy.


How has the Health Standard been developed?



A rigorous process has been undertaken on a breed-by-breed basis, to establish where each test should sit for each breed. The criteria to determine this includes:



Trends in a condition over time (i.e. prevalence, breed averages, frequency of genetic mutations etc.).
Published evidence in scientific journals to support the accuracy of a test.
Population of a breed and whether the breed has limited genetic diversity.


The Kennel Club will collect and publish health results from all three categories.



It’s important to note that the Health Standard includes all testable health conditions, including both genetic (DNA tests) and screening tests such as hip scoring or eye testing. This list is not exhaustive and, at present, only health tests that have been officially recognised by The Kennel Club have been incorporated into the Health Standard. However, the Health Standard will be regularly reviewed and is subject to change as new tests, further data, and published evidence becomes available.



Something we have not done before is incorporate the prioritisation of genetic diversity alongside health testing, and the Health Standard has been built alongside our newly revised population analyses, which have been undertaken for every registered breed.

Inbreeding concerns have been listed as a priority for several breeds, which may be due to historical breeding practices or due to small population numbers. Breeders of these breeds must follow best breeding practices and prioritise genetic diversity, in order to maintain genetic diversity within the breed. More information about the population analysis will be provided to BHCs over the next couple of months.



Below is a link to a pre-recorded presentation, which looks at the rationale behind the Health Standard and criteria which have been taken into account in its development. Please watch this video as it goes further into the methodology and meaning behind the project. We hope you have found this useful, and are sharing this with you as BHC first hand before any other Kennel Club stakeholders. We hope that you will support us with this project, by sharing this presentation with breed representatives for your breed. This webinar will also be uploaded to the BHC portal, which can be accessed here: KC Health Team - Breed Health Co-ordinators - Home (sharepoint.com)

There will be a transition over to the Health Standard, to ensure that we have one clear set of advice for breeders relating to health testing prior to breeding, however the timeframes for when this transition will take place for Assured Breeders is still to be decided. We will ensure we share an update at the earliest opportunity.

The prioritisation and justification for these changes are covered by the rationale provided in the above webinar, which I would encourage you to review. I have also attached a breakdown of each test and category, which is attached to this email. Given that there are some changes being implemented for the breed we would be willing to discuss this rationale with you as BHC in more detail, and as such would like to offer you an opportunity to discuss via Microsoft Teams. If this is something your breed community would like, please reply to this email and I will look to schedule a date/ time over the coming months to do so.

An important point to consider, throughout this process we have looked closely at the genetic diversity of each breed, in tandem with the reviewed population analyses we have been undertaking this year, and due to the findings from your breeds’ population analysis have determined genetic diversity as a key priority for some varieties. As you can see this is reflected above under the categorisation, and due to this we would recommend breeders prioritise the importance of maintaining and improving genetic diversity in the breed. We will be circulating the population analysis reports with every breed over the Summer and will be giving BHCs opportunities to meet with us to learn more about the process and what this means for your breed.

05/08/2024

Happy 16th birthday Diana - Didi - aka Danger Mouse! Beloved jumping jelly bean, strictest governess, assistant behaviourista extraordinaire, and all round badass 🤩❤️

30/07/2024

Det er lagt ut oppdatert liste over N/CDDY og N/N hunder på Gentest-siden. NDF og lokalklubber har til sammen gjennomført 22 massetester siden slutten av

28/07/2024

The IVDD conservative treatment paper from the Cambridge Vet School team has been published...

Conclusions and Clinical Importance: A high proportion of conservatively treated dogs recovered ambulation after conservative management of acute thoracolumbar disk herniation. Recovery was not dependent on the resolution of compression.

The open access paper is here:
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jvim.17149

21/07/2024

Have you had your screened under the The Kennel Club IVDD screening programme? If yes, your dog(s) could help with our research.

Bruno, our PhD student, is investigating the underlying genetics of disc calcification in Dachshunds, and he needs your dog's DNA to help him!

Read more in our news article to see how your dog could help - https://www.canine-genetics.org.uk/investigating-the-genetics-of-disc-calcification-in-dachshunds/

University of Cambridge Vet School Cambridge IVDD Research Group Southfields Veterinary Specialists Wisdom Panel



📷 PawPrints Design

12/05/2024

Exciting news from the North! 🌟 Sweden, Norway, and Finland have embarked on a journey to combat CDDY/IVDD in dachshunds through gene testing. Check out this overview from the Swedish dachshund breed club to learn more about their progress and the impact on our beloved furry friends! 🐾 "
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Sweden's first gene testing for N gene on FGF4-12 and FGF4-18

On Saturday 27/4 2024, the association Korthårsgruppen (an association for standard smooth-haired dachshunds used as hunting dogs), at its annual meeting in Ånnaboda, carried out gene testing to look for the N gene, mainly on the gene FGF4-12, which reduces the risk for dachshunds to suffer from invertebral disc herniation. The testing took place in collaboration with the Norske Dachshundklubbers Forbund, which has launched a large research project around this and will soon approach 1000 tested dachshunds.

According to previous studies, it has been assumed that the N gene is found in a single set (heterozygous = N/CDDY) in about 10% of dachshunds and in a double set (homozygous = N/N) in an extremely limited few. According to the received results, it looks like we in the Nordics, and especially within the hunting varieties, have a much better situation than in many other parts of the world.

Both in Finland and in Norway, the results of both back X-rays and of this gene test are recorded in their publicly available dog register. Sweden has the same kind of register, but currently only back X-ray scores gets registered centrally. These registers makes it possible for the Nordic dachshunds results to be compared and organized to get a better understanding for the breeds’ status. Korthårsgruppen is following the Nordic results with excitement and can state that the dachshunds that have been shown to have N/N via genetic testing and that have also had their back x-rays all have K0 or K1 on their back x-rays. As well as that the dachshunds that have been shown to have N/CDDY via genetic testing and that have also been x-rayed have back x-ray results K0-K2.

In Ånnaboda, the following were tested:

- 46 standard smoothhaired Swedish dachshunds

- 5 standard wirehaired Swedish dachshunds

- 7 standard longhaired Swedish dachshunds

- 4 dwarf longhaired Swedish Dachshunds

- 4 longhaired kaninchen Swedish dachshunds

Of the 46 standard smoothhaired, 5 were found to carry the N gene in a double set (homozygous N/N), which gives a frequency of 10.87%. These dogs will therefore inherit the N gene to all their puppies (either N/N or N/CDDY) regardless of the gene set of the dog they are mated with.

In addition to them, 15 dogs or 32.7% of those tested had the N gene in a single set and thus it already reduces the risk of herniated discs and provides opportunities to breed new dogs with the N gene.

The total frequency of the N gene on the tested hunting smooth hair dachshunds in Ånnaboda is thus 43.57%. The tested dachshunds can be considered a representative sample of the Swedish hunting smooth hair standard breed.

It is also pleasing that the N gene has been found in several lines that are not closely related to each other, and also in dachshunds’ that are the result of hairtype crossings where the N gene can come from identified carriers both within smooth hair and wire hair.

Almost every second standard smooth hair was thus found to carry the N gene, which provides enormous opportunities to minimize the herniated disc for this breed variant in Sweden, and potentially also in the Nordics. It would of course be desirable for close relatives to be gene tested and or back tested so that we can get a better picture of how many carriers of the N gene there are in Sweden. We absolutely must not already start selecting for N-carriers alone, but calmly and methodically breed the N-gene into all good lines and include all good dachshunds further in the breeding, regardless of what gene set they have. We cannot afford to limit an already thin breeding base even more.

Of the 5 wire hair that were tested in Ånnaboda, 2 were found to carry the N gene, which also gives a frequency of 40% (here you have to remember that such a small sample does not say anything about the presence of N gene in the variant as a whole). Unfortunately, none of the long-haired tested carried the N gene.

Therefore, we still need to screen the backs and use the three-year rule for many more years until we have succeeded in increasing the rate of the N gene in all varieties of dachshunds. But there is good hope for the breed to succeed in limiting the herniated disc in the long run. For us smooth hair dachshund fans, it is of course extremely gratifying that breeding excellent hunting and healthy individuals has also contributed to the N-gene being able to spread to such a high degree.

Link from where you find more information about the Norwegian research project: [https://dachshundklubb.no/ndf-styret-utvalg.../gentesting/](https://dachshundklubb.no/ndf-styret-utvalg.../gentesting/)

Testing for normalgenet Norske Dachshundklubbers Forbund (NDF) har satt i gang et gentestingsprosjekt i den norske dachshundpopulasjonen for å finne

09/05/2024

🚀 Klar for litt avlsmagi?🧬Aninova har kommet med nettkurs om avl på norsk! Det starter med grunnleggende begreper og gir kursbevis 📜🎓

Grunnleggende begreper i avlDette nettkurset tar for seg grunnleggende begreper i avl. Eksempler på begreper som forklares er innavl, arvegrad, fenotype, kromosom og heterozygoti. Et fint oppstartskurs for de videre kursene. Kurset koster 650 kroner og tar ca 1.5 time å gjennomføre. Det er spørs...

17/04/2024

Want to get to grips with the long and the short (sorry had too 😛) of dachshund genetics and IVDD in an easily digestible and entertaining way? Check out this blog post by the pawsome Perfectly Polite Dachshunds 🤩👌

3 IVDD Warriors living the good lifeI could easily write a very structured "how to" guide on the genetics that influence IVDD, but if I am honest I struggle to read beyond the first few lines, it bores the pants off me! Let alone absorb that information....ouch and yawn combo! So, my apologies to th...

08/04/2024

A great resource for getting to grips with dwarfism and IVDD in dachshunds 🐶 🧬

Short legs in dogs are caused by mutations called CDPA (chondrodysplasia) and CDDY (chondrodystrophy). Both mutations are associated with health risks, which should be considered in breeding.

04/04/2024

Here’s the second part of the interview with Bannasch where she talks about what an outcross project to get rid of a mutation looks like and how it could (or not) work for CDDY/IVDD 🧬

Danika Bannasch, DVM, PhD returns to the podcast to talk about the Dalmatian Outcross Project. Danika's laboratory found the genetic mutation that was targeted in this outcross, and she had a front row seat to the project's path to acceptance by the AKC and the Dalmatian Club of America. She is also...

17/03/2024

The UK back screening review is out! 🐶🩻

We've recently completed an analysis of the UK IVDD Screening Programme's results. There's a full report (PDF) here. This report presents the analysis of UK data to answer the question: Are dogs with 5 or more calcifications more likely to have clinical signs of Intervertebral Disc Disease (IVDD)?Th...

06/03/2024

Interested in genetics and healthy breeding? Here’s a great resource to learn more. Check out the free sample lesson to get started 🐶🐾🧬

In this self-paced online course, you will learn the basics of genetics from the very beginning and gradually progress to more challenging topics and tasks. After this course, you will understand how…

04/03/2024

🐾Exciting episode alert 🎙️Listen to the scientist who discovered the IVDD gene talk about genetics, disease, pain, behaviour and what she believes is the way forward to get rid of intervertebral disc disease 🩻

Danika Bannasch, DVM, PhD is the owner of Pint, the famous UC Davis football tee retrieving dog. She also happens to run a genetics lab, also at UC Davis, where she studies the genetics of inherited diseases in dogs and other animals. She is known for her work associating genetic variants with a var...

16/02/2024

Interesting webinar on the role of acupuncture in rehabilitation from episodes of clinical symptoms of IVDD 🐶 🩺

Medical acupuncture serves as a vital component in rehabilitation protocols for IVDD because of its effectiveness in restoring nervous system function and resolving myofascial dysfunction.

Do you want this webinar??
Comment YES if you want access!

04/11/2023

So happy and slightly nervous to get the chance to come back and talk about backs on Tiny science chat journal club again 🐶😃 With Mlin Sundqvist this time! Join us if you can 😃 To get access to the talk, fb group, and all the articles you can join the group for 5 euros a month (we meet on zoom every other Wednesday). You can unsubscribe at any time, so if you only want to join for this one talk you can cancel again right after. Although if you’re passionate about the science of dogs you might want to stay https://www.nordicdogtrainer.com/tiny-science-chat-club/