17/02/2021
Ever heard of Sulphorapane? It's a beneficial molecule that is found in cruciferous vegetables - especially in the microgreen stage.
Sulforaphane is produced when its precursor glucoraphanin is broken up, releasing the enzyme myrosinase, either by crushing, chewing, light heating, blending, or even freezing.
Glucoraphanin is found in cruciferous vegetables such as cabbage, kale, broccoli, brussel sprouts, mustard. Broccoli sprouts and microgreens have been found to have significantly higher levels, up to 100x more.
Sulforaphane has been found to activate the NRF2 pathway which commands over 200 genes including antioxidant, anti-inflammatory genes, and genes that make harmful compounds inactive. Interestingly the NRF2 pathways is naturally activated in the body every 129 minutes, but when stimulated with sulforaphane it is activated every 80 minutes.
Consumption of cruciferous vegetables, 1-2 servings (1/2-1 cup) per day has been associated with lower risk of breast cancer, bladder cancer, lung cancer, prostate cancer, and cardiovascular disease – isothiocynates, of which sulforaphane is one, are the likely cause.
Sulforaphane has been linked to preventing the activation of Phase 1 Biotransformation Enzymes which have been associated with the conversion of pro-carcinogenic compounds into active carcinogens. Isothiocynates have also been found to activate Phase II Detoxification Enzymes which help to deactivate pro-carcinogenic compounds converting them into water-soluble compounds easily excreted from the body.
Sulforaphane has also been found to prevent DNA Adducts which is a type of damage to DNA shown to lead to cancer. Adducts not removed or expelled from the body cause mutations and increase the risk of cancer.
Sulforaphane may help to slow the aging process by reducing inflammation. Inflammation has been identified as a significant factor in aging, impacting physical ability, cognitive function, and increasing the risk of disease making people more susceptible to infection.
In one of study, sulforaphane was found to reverse hair loss and baldness in mice through the degradation of dihydrotestosterone which is responsible for reducing hair growth.
In animal studies, sulforaphane, and its precursor glucoraphanin, administered to depressed mice reduced depressive behaviors such as the avoidance of social situations. I’m not aware if any human studies yet though.
In other animal studies, sulforphane had positive impacts on alzheimers, parkinsons, and huntingtons disease. All of which have a relationship with brain inflammation, oxidative stress, reactive oxygen species, and abnormal protein aggregates. Things that sulforaphane has been shown to positively impact in other studies.
Here is Dr Rhonda Patrick going into detail about the wonders of Sulphoraphane
https://youtu.be/zz4YVJ4aRfg