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Successes
Researchers around the world continue to explore ibogaine’s potential medical uses — in particular, its use as a treatment for addiction and neuropsychiatric conditions. Thousands of studies have investigated the different properties of ibogaine, its potential uses, and its effectiveness. Currently, Brazil, South Africa, and New Zealand classify ibogaine as a pharmaceutical substance that licensed medical professionals can use.
Some researchTrusted Source suggests that ibogaine somehow changes addiction-related or promoting pathways between nerve cells in the brain. It may also affect signaling in brain regions that play a role in the behavioral effects of drugs that are addictive.
Hallucinogens such as ibogaine may also activateTrusted Source the 5-HT2A serotonin receptor (HTR2A). Serotonin is a brain hormone that helps improve mood, happiness, and feelings of well-being.
In a 2014 study in Brazil, researchers recruited 75 participants who previously used cannabis, co***ne, crack co***ne, or alcohol. The participants who received one ibogaine treatment reported abstaining from drug use for a median of 5.5 months. Those who received multiple ibogaine treatments abstained for a median of 8.4 months.
The Multidisciplinary Association for Psychedelic Studies (MAPS) also helped fund two observational studies in 2017 that supported the use of ibogaine as a treatment for addiction to drugs.
In the first of these studies, which took place in Mexico, ibogaine use improved symptoms of opioid withdrawal and reduced subsequent drug use in people who had found other treatment options ineffective.
In the other study, researchers in New Zealand concluded that a single treatment with ibogaine reduced symptoms of opioid withdrawal in people dependent on opioids over 12 months. It also helped people stop taking opioids or maintain a reduced use. However, one person in the study died during treatment.
Some researchersTrusted Source are currently trying to modify
Other psychedelics to treat addiction
Open-label studies and anecdotal reports also supportTrusted Source the use of psychedelic drugs for addiction treatment, including lysergic acid diethylamide (L*D) and psilocybin, which contains the active ingredient psilocin.
The psychiatric community has suggested a few other psychedelics as treatments for addiction, including:
ketamine
ayahuasca
pe**te (mescaline)
substituted N-benzyl phenylalkylamines
N,N-dimethyltryptamine (DMT)
kratom
3,4-methylenedioxymethamphetamine (M**A)
salvia
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