Dr. Thomas Seyfried

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Dr. Thomas Seyfried * Author, Cancer As A Metabolic Disease
* Ph.D., University of Illinois, Urbana-Champaign
* Boston College Professor of Biology

07/07/2025

Cancer cells require both the sugar glucose and the amino acid glutamine to proliferate and stay alive -- these two fuels are fermented (energy without oxygen) by cancer cells even in the presence of oxygen due to their damaged mitochondria/disturbed energy metabolism. Thus, the strategy for managing cancer HAS to include the targeting of these two fuels by entering deep ketosis (through diet) and using repurposed metabolic drugs (to target glutaminolysis), effectively cutting off the fuel supply of cancer cells while transitioning the rest of the body to ketones and fatty acids for energy (which require healthy mitochondria to burn for energy)!

This non-toxic strategy for managing cancer is called Ketogenic Metabolic Therapy, if you want to learn more about implementing it into the cancer care process comment "KMT" below to be sent the info with links to our published protocol papers.

01/06/2025

Join my newly created Facebook group Dr Thomas Seyfried Cancer Study Group and Protocol , you will find out more about my cancer protocol and approach.

31/05/2025

Dr. Seyfried describes the standard of care for glioblastoma. The combination of radiation and steroid drugs raise blood sugar and glutamine, ultimately fueling tumor cells.

The survival curve graphs shown are from a paper which can be accessed here: https://www.mdpi.com/1701642

The paper on Mediterranean keto diet interventions by Dr. Seyfried and colleagues discussed in the interview can be found here: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1489812/full

The paper that the field of oncology has utilized to develop the GBM standard of care can be found here: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(09)70025-7/abstract

This clip was taken from an interview with Professor Seyfried that can be found on his official YouTube channel: https://youtu.be/VeoYMgjnyNE?feature=shared

Subscribe to the official YouTube channel for more interviews and discussions on cancer at "Talking Cancer With Professor Thomas Seyfried": www.youtube.com/-u4k

Learn more about cancer as a metabolic disease by checking out the book “Cancer as a Metabolic Disease” which is linked in my bio. Feel free to read the dozens of peer-reviewed research articles that support this by searching “Thomas Seyfried” on Google scholar (most papers are open access there).

Dr. Thomas Seyfried and colleagues have published a crucial new paper in the Journal of Bioenergetics and Biomembranes.L...
31/05/2025

Dr. Thomas Seyfried and colleagues have published a crucial new paper in the Journal of Bioenergetics and Biomembranes.

Link to read the free access paper: https://doi.org/10.1007/s10863-025-10059-w

The paper presents the historical and current scientific evidence required to force a paradigm shift in the cancer field.

For the American Cancer Society 2025 cancer statistics mentioned, click this DOI link: 10.3322/caac.21871

07/05/2025

Do not be left out, every opinion and experience counts. We are newly building our community Dr Thomas Seyfried Cancer Study Group and Protocol to share and reveal the truth about cancer and the big pharma.

18/04/2025

Dr. Seyfried describes the standard of care for glioblastoma. The combination of radiation and steroid drugs raise blood sugar and glutamine, ultimately fueling tumor cells.

The survival curve graphs shown are from a paper which can be accessed here: https://www.mdpi.com/1701642

The paper on Mediterranean keto diet interventions by Dr. Seyfried and colleagues discussed in the interview can be found here: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1489812/full

The paper that the field of oncology has utilized to develop the GBM standard of care can be found here: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(09)70025-7/abstract

This clip was taken from an interview with Professor Seyfried that can be found on his official YouTube channel: https://youtu.be/VeoYMgjnyNE?feature=shared

Subscribe to the official YouTube channel for more interviews and discussions on cancer at "Talking Cancer With Professor Thomas Seyfried": www.youtube.com/-u4k

Learn more about cancer as a metabolic disease by checking out the book “Cancer as a Metabolic Disease” which is linked in my bio. Feel free to read the dozens of peer-reviewed research articles that support this by searching “Thomas Seyfried” on Google scholar (most papers are open access there).

Follow Professor Seyfried's official TikTok at: thomasseyfriedbc

14/04/2025

Cancer as a Mitochondrial Metabolic Disease is the next revolutionary credible theory.

Watch Dr. Seyfried’s full lecture on the Broken Science Initiative Youtube Channel — Cancer as a Mitochondrial Metabolic Disease: Thomas Seyfried

24/03/2025

The field of cancer research has spent decades studying the nucleus of the cancer cell and its chaotic mutational landscape, believing that it is those genetic mutations that cause the cancer to form. However, overwhelming research has shown the existence of cancer cells without mutations and healthy cells with mutations which never become cancer.
The simple truth is that the origin of cancer is not in the nucleus and its mutations, but in the chronic damaging of the mitochondria. Cancer is inherently a problem of aberrant metabolism, or cell growth out of control. Mutations can be risk factors for cancer, and/or could also be downstream effects of a disturbed energy metabolism (mutagenic ROS released by damaged mitochondria).
The cancer cell forms when the mitochondria are corrupted (by any number of processes which cause oxidative stress like smoking and being obese, for example) and avoid cell death by getting energy from fermentation metabolism, compensating for the impaired (normal) energy production from oxidative phosphorylation. We can see the structural damage of mitochondria in cancer cells via the electron microscope.
Every cancer cell is by definition locked into a fermentative metabolism - using primarily glucose (sugar) and glutamine (amino acid) for energy - without these two fuels the cancer cells are unable to continue growing, thus the targeting of these two fuels (getting into ketosis to target glucose and pulsing metabolism-targeted drugs like DON or fenbendazole/mebendazole to target glutamine) while keeping the rest of the body healthy (exercise + keto/fasting) should be a priority for managing cancer.
To learn more about cancer as a metabolic disease and how to manage it with metabolic therapies, check out the link in our bio for our newsletter and more links to resources like videos, articles, and other media. Our research is free to access on Google Scholar (just look up “Thomas Seyfried” and “cancer as a metabolic disease”).

For our Spanish-speaking audience, join Dr. Duraj, postdoctoral research fellow in Dr. Seyfried's lab, for this 2+ hour ...
09/03/2025

For our Spanish-speaking audience, join Dr. Duraj, postdoctoral research fellow in Dr. Seyfried's lab, for this 2+ hour conversation about ketogenic metabolic therapy on the Oncología Metabólica podcast.

Para nuestra audiencia de habla hispana, puedes aprender más sobre la terapia metabólica cetogénica en el podcast de Oncología Metabólica entrevistando al Dr. Duraj, investigador postdoctoral en el laboratorio del Dr. Seyfried.

Link al podcast:
https://oncologiametabolica.com/episodio/episodio-19-tomas-duraj/



If you want to read the paper, find it here: https://doi.org/10.1186/s12916-024-03775-4

You can learn more about our recent publications or support us via donation at the Boston College Dr. Thomas Seyfried Faculty website.
https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.html

07/03/2025

In this interview with Dr. Mark Hyman, Dr. Seyfried discusses the metabolism of cancer cells and his team's research, which builds upon the theories of Nobel Prize winning scientist Dr. Otto Warburg. Cancer cells' two primary fuels are glucose and the amino acid glutamine. By "pulling the plug" on both fuels, cancer cells cannot obtain energy, while healthy cells (with healthy mitochondria) can switch to alternative metabolic pathways, such as using ketone bodies (products of fat metabolism).

The full interview can be found on YouTube at this link: https://youtu.be/nGo0mtPX-JQ?feature=shared

Subscribe to the official YouTube channel for more interviews and discussions on cancer at "Talking Cancer With Professor Thomas Seyfried": www.youtube.com/-u4k

Learn more about cancer as a metabolic disease by checking out the book “Cancer as a Metabolic Disease” which is linked in my bio. — Feel free to read the dozens of peer-reviewed research articles that support this by searching “Thomas Seyfried” on Google scholar (most papers are open access there).

Follow Professor Seyfried's official TikTok at: thomasseyfriedbc

03/03/2025

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