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The Veterinary Void Embracing the chaos. Memes for Veterinary Professionals.

Your patients are waiting for your help. Have a great week. cc: ⁠⁠                                                      ...
24/09/2023

Your patients are waiting for your help. Have a great week. cc: ⁠

☹️
31/08/2023

☹️

MOA Monday: Methotrexate (MTX) ⁠⁠MTX is a well-recognised drug in veterinary oncology, primarily used to counteract the ...
28/08/2023

MOA Monday: Methotrexate (MTX) ⁠

MTX is a well-recognised drug in veterinary oncology, primarily used to counteract the aggressive growth of cancerous tumours by targeting cells that divide at a rapid pace. Its mechanism is based on its ability to act as a decoy for folic acid, a crucial component for cell division. By doing so, MTX effectively inhibits the enzyme dihydrofolate reductase (DHFR). This enzyme is instrumental in converting dihydrofolate to tetrahydrofolate, a key molecule needed for producing nucleotides for DNA synthesis. As cancerous cells in animals are in a constant state of division and growth, they have a heightened demand for these nucleotides. When MTX interferes with their production, it results in a significant disruption of the cancer cell's ability to replicate and grow.⁠

However, it's worth noting that like many chemotherapy drugs, methotrexate affects both cancerous and healthy cells, especially those that naturally divide quickly, such as cells in the bone marrow, digestive tract, and hair follicles. This action can lead to some of the common side effects of chemotherapy, like fur thinning or whisker loss, mouth sores, and decreased blood cell counts.⁠

There's nothing wrong with advocating for quality drug use. Mechanism of action Monday: Xylitol                         ...
24/08/2023

There's nothing wrong with advocating for quality drug use.
Mechanism of action Monday: Xylitol

Stop breathing so loudly. ⁠⁠
23/08/2023

Stop breathing so loudly. ⁠

22/08/2023

(This is AR and not showing a live image)

If the owner doesn't stop letting Toby call the shots, they can add a monthly Solensia to the roster soon. ⁠⁠           ...
21/08/2023

If the owner doesn't stop letting Toby call the shots, they can add a monthly Solensia to the roster soon. ⁠

We're all allowed to have our moments. You're allowed more of them when you're that cute.                               ...
19/08/2023

We're all allowed to have our moments. You're allowed more of them when you're that cute.

Fine Art Friday no. 4! 🎨🖌️
18/08/2023

Fine Art Friday no. 4! 🎨🖌️

Back to the drawing board...
17/08/2023

Back to the drawing board...

It's been a long week, but thank you.
16/08/2023

It's been a long week, but thank you.

I feel like the Sisyphus of small animals. Medicine and surgery are the hobbies, admin and communication is the job.⁠⁠  ...
15/08/2023

I feel like the Sisyphus of small animals. Medicine and surgery are the hobbies, admin and communication is the job.⁠

14/08/2023

Mechanism of action Monday: Xylitol

Xylitol is a sugar substitute in human foods and a potent toxin in dogs.

Here's the pathophysiology of xylitol ingestion in dogs:

1. Rapid Absorption: Xylitol is quickly absorbed from the canine gastrointestinal tract.

2. Insulin Release: Xylitol then leads to a rapid and pronounced insulin release from the pancreas. This is due to xylitol's ability to stimulate insulin secretion directly in the pancreas.

3. Hypoglycemia: The significant release of insulin leads to hypoglycemia. The syxmptoms of hypoglycemia can manifest within 10-60 minutes following xylitol ingestion and include vomiting, loss of coordination, lethargy, incoordination, tremors, seizures, and in severe cases, coma.

4. Liver Toxicity: Apart from the hypoglycemic effects, xylitol has been associated with acute hepatic necrosis in dogs. The exact mechanism for this liver toxicity is still not well-understood. Increased liver enzymes can be detected on blood tests, and in severe cases, it can lead to complete liver failure.

5. Other Effects: Xylitol can lead to potassium release into the bloodstream, resulting in hyperkalemia (increased potassium levels), which can affect cardiac function.

6. Species Differences: In cats, the available evidence to date suggests they might not experience the rapid insulin release and subsequent hypoglycemia that dogs do.

Given its potentially fatal consequences, it's vital for pet owners to be aware of xylitol-containing products in their households and to keep them out of reach of their pets. Immediate veterinary attention is necessary if xylitol ingestion is suspected in a dog.

Please help me, from arm's length. I just need a few days. 😰
14/08/2023

Please help me, from arm's length. I just need a few days. 😰

Get a catheter in Luna, I'll tell the owner now. I think we're early enough.                                            ...
12/08/2023

Get a catheter in Luna, I'll tell the owner now. I think we're early enough.

Fine Art Friday No. 3. 🎨🖌️⁠⁠
11/08/2023

Fine Art Friday No. 3. 🎨🖌️⁠

11/08/2023

There's usually one in every practice. They give the best of care, but definitely have their preference if pushed...

Your morning walk in emergency coming back to bite you.
10/08/2023

Your morning walk in emergency coming back to bite you.

10/08/2023

🎼Don't be suspicious 🎶

Honey, I'm (not going to be) home!
09/08/2023

Honey, I'm (not going to be) home!

09/08/2023

🫠

What's your go-to line to ensure client compliance?
08/08/2023

What's your go-to line to ensure client compliance?

07/08/2023

Mechanism of action Monday: ⁠
Lidocaine is a local anesthetic that also has antiarrhythmic properties. ⁠

Here's how it works:⁠

1. Voltage-Gated Sodium Channel Blockade: ⁠
Lidocaine's primary antiarrhythmic mechanism is its blockade of voltage-gated sodium channels in cardiac myocytes. By binding to these channels, it inhibits the rapid influx of sodium ions into the cell during the depolarization phase.⁠

2. Fast-Dissociation: ⁠
Unlike some other antiarrhythmic drugs, lidocaine quickly associates and dissociates from the sodium channel. This allows it to preferentially affect cells that are abnormally depolarizing more frequently than they should, such as those undergoing repetitive depolarizations seen in ventricular arrhythmias.⁠

3. Shortened Refractory Period: ⁠
By blocking sodium channels and prolonging the refractory period, lidocaine prevents cells from being re-excited prematurely, which can help stop the arrhythmia.⁠

4. Decrease in Abnormal Automaticity: ⁠
Ventricular arrhythmias can arise due to increased automaticity (abnormal spontaneous firing of electrical impulses). By blocking sodium channels, lidocaine can reduce or eliminate these abnormal impulses.⁠

5. Focus on Ischemic Tissues: ⁠
Lidocaine has a particular affinity for ischemic tissues, this makes lidocaine especially effective in treating arrhythmias that arise in the context of certain toxicities.⁠


Lidocaine is often used as an emergency drug to treat ventricular arrhythmias, especially in the perioperative period or in cases of toxin ingestion. It's one of the first-line drugs for this purpose due to its rapid onset of action when given intravenously.⁠

At what point do you admit defeat and submit to being perpetually covered in a light coat of fur?                       ...
07/08/2023

At what point do you admit defeat and submit to being perpetually covered in a light coat of fur?

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