FCoV Free Cats

01/12/2024

Great new - another antiviral that clears fcv.
⭐️ Where to buy Mol read HERE ⭐️
Molnupiravir treatment
(EIDD 2801)

Below is the most effective treatment plan for 8 weeks:

For all Calicivirus (FCV) related symptoms: 20 mg/kg/day (10 mg/kg twice daily)
Chronic symptoms: 40 mg/kg/day (20 mg/kg twice daily)

Available from different indiamart brokers.

03/10/2024

FIP - Different Drugs and their dosages
DON'T STOP TREATMENT until AGP level of cats, is below 500.

Molnupiravir (EIDD 2801)
Below is the most effective treatment plan for 8 weeks:
For wet FIP and by implication stopping FCoV shedding: 20 mg/kg/day (10 mg/kg twice daily)
Non-effusive: 30 mg/kg/day (15 mg/kg twice daily)
Neurological or ocular signs: 40 mg/kg/day (20 mg/kg twice daily)
There are 2 protocols used, for Neuro FIP:
1. Neurological or ocular signs: 40 mg/kg/day (or 20 mg/kg twice daily)
Start treatment on higher dose; Then when neurological symptoms are resolved and bloods are more normal levels, reduce dose to: Non-effusive: 30 mg/kg/day (15 mg/kg
twice daily).
2. Neurological or ocular signs: 40 mg/kg/day (or 20 mg/kg twice daily)
Stay on this dosage throughout treatment.
Duration of treatment 5-10 weeks depending on the severity of the disease and the particular cat.

Mutian
The dosing for non-neuro and no ocular symptoms cats is 100mg/kg per day.
For ocular symptoms, 150mg/kg per day.
For neuro symptoms, it is 200mg/kg per day.

Bova GS-441524
Effusion(s) and without ocular or neurological signs 15 mg/kg q 24 hrs or split q 12 hrs
No effusion and without ocular or neurological signs 15 mg/kg q 24 hrs or split q 12 hrs
Ocular signs present (± effusion) 15-20 mg/kg q 24 hrs or split q 12 hrs
Neurological signs present (± effusion) 10 mg/kg q 12 hrs

GPLS
GS capsules comes with different GS content:
GPLS, 80mg – 20 GS
GPLS, 60mg – 15 GS
GPLS, 40mg – 10 GS
GPLS, 25mg - 7,5 GS

17/02/2024

We often get asked about Herpes virus. Here is a study using Raltegravir. It clears the virus from the host, you should get a PCR negative. (cat stops shedding)

Sold as 400mg tablets.
Cat use 27mg/Kg.
PO bd q12*14 (orally. every 12 hours for 14 days).

One pill treats 15Kg cat.
A 3Kg cat needs 2 doses of 81mg bd (twice per day), so 28 doses for a 14 day treatment = 5 2/3 tablets
A 4kg cat ... 108mg ... 7.5 tablets

Abstract OBJECTIVE To determine the effects of orally administered raltegravir in cats with experimentally induced ocular and respiratory feline herpesvirus-1 (FHV-1) infection. ANIMALS 14 healthy 6-month-old unvaccinated specific pathogen–free cats. PROCEDURES On day 0, all cats were experimental...

17/02/2024

Another virus bites the dust.
Say good by to Calici virus with Nitazoxanide (NTZ)

Cats typically receive a dose of 25 mg/kg every 12-24 hours until the condition resolves.

Should a scheduled dose be missed, it should be administered as soon as possible. If it is almost time for the next scheduled dose, the missed dose should be skipped and the regular medication schedule should be continued. Two doses of nitazoxanide should not be administered at the same time.

Nitazoxanide is an antiparasitic agent that is used to treat a variety of protozoa, bacteria, nematodes, and trematodes. It is useful against sarcocystis neurona, giardia, cryptosporidia, and helicobacter pylori.

It is useful against severe Gingivitis, inflammation of the gum or gingiva.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306210/ #:~:text=Nitazoxanide%20protects%20cats%20from%20feline,with%20mizoribine%20in%20vitro%20%2D%20PMC&text=The%20.

17/02/2024

⭐️ Where to buy Mol read HERE ⭐️
Molnupiravir treatment of 18 cats with feline infectious peritonitis: A case series.

Molnupiravir (EIDD 2801)

Below is the most effective treatment plan for 8 weeks:

For wet FIP and by implication stopping FCoV shedding: 20 mg/kg/day (10 mg/kg twice daily)
Non-effusive: 30 mg/kg/day (15 mg/kg twice daily)
Neurological or ocular signs: 40 mg/kg/day (20 mg/kg twice daily)

There are 2 protocols used, for Neuro FIP:
1. Neurological or ocular signs: 40 mg/kg/day (or 20 mg/kg twice daily)
Start treatment on higher dose; Then when neurological symptoms are resolved and bloods are more normal levels, reduce dose to: Non-effusive: 30 mg/kg/day (15 mg/kg twice daily).

2. Neurological or ocular signs: 40 mg/kg/day (or 20 mg/kg twice daily)
Stay on this dosage throughout treatment.
Duration of treatment 5-10 weeks depending on the severity of the disease and the particular cat.
DON'T STOP TREATMENT until AGP level of cats, is below 500.

***REMEMBER to weight the cat weekly as they put weight on, you will need to adjust the dosage of the drug.****

Available from indiamart brokers: mailto:[email protected]
Minimum orders apply

Feline infectious peritonitis (FIP) is a viral disease in cats, caused by certain strains of coronavirus and has a high case fatality rate.This case series reports the outcomes of treatment of cats with FIP using molnupiravir.Eighteen cats diagnosed with ...

17/01/2024

🇬🇧 UK information. Raltegravir works against DNA viruses, used against FHV-1. Herpes.
It clears the virus.

Raltegravir and Molnupiravir are made in the UK by Merck Sharp & Dohme (UK) Ltd
Lagevrio 200mg capsules
120 Moorgate, London EC2M 6UR
[email protected]


Alliance Healthcare are the only distributors for it. However to obtain it as Vet meds, an account needs to be opened by the Vet practice.
W: www.alliance-healthcare.co.uk

Below are PubMed about Raltegravir

Inhibition of Feline leukemia virus replication by the integrase inhibitor Raltegravir.
Cattori V, Weibel B, Lutz H.Vet Microbiol. 2011 Aug 26;152(1-2):165-8. doi: 10.1016/j.vetmic.2011.03.039. Epub 2011 Apr 12.PMID: 21570781
The oncogenic gammaretrovirus Feline leukemia virus (FeLV) has been the leading cause of death among domestic cats until the introduction of efficient diagnostics and vaccines in the late 1980s. ...Therefore, Raltegravir may be a potential therapeutical agent …

Effects of orally administered raltegravir in cats with experimentally induced ocular and respiratory feline herpesvirus-1 infection.
Spertus CB, Pennington MR, Van de Walle GR, Badanes ZI, Judd BE, Mohammed HO, Ledbetter EC.Am J Vet Res. 2019 May;80(5):490-497. doi: 10.2460/ajvr.80.5.490.PMID: 31034270 Free article.
OBJECTIVE: To determine the effects of orally administered raltegravir in cats with experimentally induced ocular and respiratory feline herpesvirus-1 (FHV-1) infection. ...Cats were randomly assigned to receive either raltegravir (80 mg; n = 7) …

Undetectable proviral DNA and viral RNA levels after raltegravir administration in two cats with natural feline leukemia virus infection.
Santos CRGR, Ferreira IT, Beranger R, Santi JP, Jardim MPB, de Souza HJM.Braz J Vet Med. 2022 Oct 26;44:e003522. doi: 10.29374/2527-2179.bjvm003522. eCollection 2022.PMID: 36324639 Free PMC article.
This report describes the use of an antiretroviral integrase inhibitor, raltegravir, in two cats with natural FeLV infection. Raltegravir was administered orally at a dose of 40 mg/cat every 12 h in both cases. ...To our knowledge, this is the first report de …

Evaluation of the effect of short-term treatment with the integrase inhibitor raltegravir (Isentress) on the course of progressive feline leukemia virus infection.
Boesch A, Cattori V, Riond B, Willi B, Meli ML, Rentsch KM, Hosie MJ, Hofmann-Lehmann R, Lutz H.Vet Microbiol. 2015 Feb 25;175(2-4):167-78. doi: 10.1016/j.vetmic.2014.10.031. Epub 2014 Nov 3.PMID: 25500005
Cats persistently infected with the gammaretrovirus feline leukemia virus (FeLV) are at risk to die within months to years from FeLV-associated disease, such as immunosuppression, anemia or lymphoma/leukemia. ...The seven cats were treated during nine weeks ( …

The HIV Integrase Inhibitor Raltegravir Inhibits Felid Alphaherpesvirus 1 Replication by Targeting both DNA Replication and Late Gene Expression.
Pennington MR, Voorhees IEH, Callaway HM, Dehghanpir SD, Baines JD, Parrish CR, Van de Walle GR.J Virol. 2018 Sep 26;92(20):e00994-18. doi: 10.1128/JVI.00994-18. Print 2018 Oct 15.PMID: 30045987 Free PMC article.
We have previously shown, both in vitro and in vivo, that raltegravir can also inhibit the replication of felid alphaherpesvirus 1 (FeHV-1), a common ocular pathogen of cats with a pathogenesis similar to that of HHV-1 ocular disease. ...A candidate-based approach t …

A novel corneal explant model system to evaluate antiviral drugs against feline herpesvirus type 1 (FHV-1).
Pennington MR, Fort MW, Ledbetter EC, Van de Walle GR.J Gen Virol. 2016 Jun;97(6):1414-1425. doi: 10.1099/jgv.0.000451. Epub 2016 Mar 9.PMID: 26959283
Feline herpesvirus type-1 (FHV-1) is the most common viral cause of ocular surface disease in cats. ...Raltegravir was not toxic to feline cells or corneas, and most significantly, inhibited FHV-1 replication at 500 M in both systems. ...

Transcriptome profiling of alphaherpesvirus-infected cells treated with the HIV-integrase inhibitor raltegravir reveals profound and specific alterations in host transcription.
Pennington MR, Grenier JK, Van de Walle GR.J Gen Virol. 2018 Aug;99(8):1115-1128. doi: 10.1099/jgv.0.001090. Epub 2018 Jun 19.PMID: 29916804
Interestingly, raltegravir can also directly inhibit the replication of various herpesviruses. ...Using RNA deep sequencing, we found that raltegravir specifically boosts the expression of anti-angiogenic factors and promotes metabolic homeostasis in FHV-1-infected …

Discovery of drugs that possess activity against feline leukemia virus.
Greggs WM, Clouser CL, Patterson SE, Mansky LM.J Gen Virol. 2012 Apr;93(Pt 4):900-905. doi: 10.1099/vir.0.039909-0. Epub 2012 Jan 18.PMID: 22258856 Free PMC article.
Feline leukemia virus (FeLV) is a gammaretrovirus that is a significant cause of neoplastic-related disorders affecting cats worldwide. ...This study demonstrates the anti-FeLV activity of four drugs approved by the US FDA (Food and Drug Administration) at non-toxic …

Presumptive hemophagocytic syndrome associated with co-infections with FIV, Toxoplasma gondii, and Candidatus mycoplasma haemominutum in an adult cat.
Fonseca J, Silveira J, Faísca P, de Almeida PM.Vet Clin Pathol. 2023 Jun;52(2):324-333. doi: 10.1111/vcp.13205. Epub 2023 Mar 28.PMID: 36975170
A 9-year-old neutered male cat, previously test-positive for feline immunodeficiency virus (FIV), was presented with an history of vomiting, hyporexia, and weight loss. ...PCR testing was positive for Candidatus Mycoplasma haemominutum and IgG antibodies against Toxoplasma …

Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents.
Togami H, Shimura K, Okamoto M, Yoshikawa R, Miyazawa T, Matsuoka M.J Virol. 2013 Apr;87(8):4322-9. doi: 10.1128/JVI.03208-12. Epub 2013 Jan 30.PMID: 23365453 Free PMC article.
Among these, two HIV reverse transcriptase inhibitors, zidovudine (AZT) and tenofovir disoproxil fumarate (TDF), potently inhibited SRV-4 infection within a submicromolar to nanomolar range, which was similar to or higher than the activities against HIV-1, Moloney murine leukemia …

Alliance Healthcare UK is a leading distributor and wholesale supplier of pharmaceutical, surgical, medical & healthcare products around the world.

11/01/2024

Interesting read for breeders and cat owners. Is this the new normal… for cat breeding. The transmission of SARS-COV-2 from human to cat, is now well documented. Purebred cats are more susceptible to the virus. (This research paper was published in Viruses. Viruses is a peer-reviewed, open access journal of virology, published monthly online by MDPI. The American Society for Virology (ASV))

The lower immunity response to the virus, the ease of transmission for example in the Omicron variant and level of infection in cats vary between the different virus mutations, mirroring the human infection and transmission rates.

There has been an increase of breeders having to stop breeding because they can not manage the continuous outbreak of ‘strange’ respiratory illnesses in their cats and litters.

The secondary infections appear, as the immunity decreases and viral loads increase.

Common secondary infections or diseases that can be observed or tested for are:

Mycoplasma
Upper respiratory infections
Lethargy
Chronic eye infection
Mouth ulcers
Gingivitis, periodontitis
Cough
FIP

This paper was published in 2023, it’s one of the first to discuss what’s going on.

Note: A cat infected with SARS-COV-2, is not the same as a cat infected with FCoV, however with the low immune response to SARS-COV-2, would mean that the FCoV viral load in a SARS-COV-2 infected cat would increase. It is documented that high FCoV viral loads in individual cats and cohorts of cats can lead to the development of the FIP disease in some cases.

Would this explain why there is an increase of FIP and new FIP virus variants in cat around the world?

Our conclusion: Limit how your cat can be exposed to CovID.
Everyone

Throughout the COVID-19 pandemic, SARS-CoV-2 infections in domestic cats have caused concern for both animal health and the potential for inter-species transmission. Cats are known to be susceptible to the Omicron variant and its descendants, however, ...