酵母菌和他的朋友們 Budding Yeast and Friends

12/08/2021

Cis - variants shape gene expression revealed

https://elifesciences.org/articles/68469

Evolution of cis-regulatory sequences depends on how they affect gene expression and motivates both the identification and prediction of cis-regulatory variants responsible for expression differences within and between species. While much progress has been made in relating cis-regulatory variants to...

12/08/2021

co-evolve

https://www.embopress.org/doi/full/10.15252/msb.202010189🐳🐬

Adaptive laboratory evolution of obligatory mutualistic communities shows how coevolution can be used for targeted improvement in fitness-costly metabolite secretion.

12/08/2021

larger cell smaller nuclei 🐘🐭

https://onlinelibrary.wiley.com/doi/10.1002/evl3.243

Larger cells have larger nuclei, but the precise relationship between cell size and nucleus size remains unclear, and the evolutionary forces that shape this relationship are debated. We compiled dat...

28/07/2021

Bottleneck size & antibiotic resistance

Strong population bottlenecks in combination with weak antibiotic selection consistently favours the evolution of resistance across independently performed Pseudomonas aeruginosa evolution experiments.

28/07/2021

evolution of SARS-CoV2

One year into the global COVID-19 pandemic, the focus of attention has shifted to the emergence and spread of SARS-CoV-2 variants of concern (VOCs). A…

26/07/2021

in vivo experimental evolution of Mycobacterium tuberculosis in mice
https://www.nature.com/articles/s41564-021-00938-4

In vivo experimental evolution of Mycobacterium canettii populations reveals enhanced persistence of evolved mutants due to resistance to host-derived stresses, providing insight into the emergence of persistent Mycobacterium tuberculosis.

23/07/2021

Candida auris . 極度抗藥念珠菌出現
https://www.forbes.com/sites/brucelee/2021/07/23/cdc-candida-auris-outbreaks-how-this-fungus-has-become-even-more-dangerous/

Outbreaks of the yeast Candida auris in Washington, DC, and Texas have included versions of the fungus that were pan-resistant, resistant to all typically used anti-fungal medications.

22/07/2021

together stronger

https://www.nature.com/articles/s41559-021-01505-0

A clever experimental design in bacteria with engineered obligate mutualisms shows that interdependency can allow pairs of bacteria to survive in environments that are uninhabitable by the individual strains.

16/07/2021

Enhanced mtDNA stability evolved.
https://www.cell.com/current-biology/fulltext/S0960-9822(21)00821-6

To shed light on how cells can improve their mitochondrial quality control system and adapt to mitochondrial stress, Amine et al. evolve the budding yeast under laboratory selection. Their results show that multiple pathways are altered to enhance mDNA stability and the evolved mutations also lengt...

16/07/2021

Modeling of virulence and community dynamics of fungal foliar pathogens on the invasive plant Ageratina adenophora
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009769

Author summary A growing number of examples indicate that many plant diseases are caused by multiple taxa of microbes. Therefore, how virulence evolves in the context of multiple infections by different species with both vertical and horizontal transmission modes represents an important area of path...

24/12/2019

Engineered co-cultures of yeast & bacteria
https://www.biorxiv.org/content/10.1101/2019.12.20.882472v1

Biological systems assemble tissues and structures with advanced properties in ways that cannot be achieved by man-made materials. Living materials self-assemble under mild conditions, are autonomously patterned, can self-repair and sense and respond to their environment. Inspired by this, the field...

24/12/2019

Streptophyte algae
https://www.nature.com/articles/s41477-019-0560-3

A study sequenced and analysed two genomes of basal streptophyte algae that adapt to freshwater and subaerial/terrestrial environments, respectively, providing insights into plant terrestrialization, an important evolutionary transition in the history of life.

24/12/2019

Evolving antibiotic resistance proteins in E.coli

https://www.cell.com/cell-systems/fulltext/S2405-4712(19)30428-4

We asked whether experimental evolution, similar to natural evolution, generates enough information about amino acid residue interactions to determine protein structure. We mimicked the natural evolution of two distinct antibiotic resistance proteins using an iterative mutation-selection process. Fr...

20/12/2019

Turn Pichia pastoris into autotroph .
https://www.nature.com/articles/s41587-019-0363-0

A yeast species used to produce proteins and chemicals is engineered to grow solely on the greenhouse gas CO2.

19/12/2019

cooperative replicators
https://www.nature.com/articles/s41559-019-1039-3

The origin of life would have required enzymatic cooperation that was not susceptible to cheating replicators. The authors show theoretically that this does not require a cell membrane and instead can arise when enzymatic cooperation and physical association coevolve.

17/12/2019

Ernst Haeckel on the synthesis of Darwinism

https://www.cell.com/current-biology/fulltext/S0960-9822(19)31436-8?dgcid=raven_jbs_etoc_email

Georgy Levit and Uwe Hossfeld reflect on Ernst Haeckels place in the history of biology on occasion of the 100th anniversary of his death.

11/12/2019

18.5% of gene deletion phenotypes change between any pair of strains
https://www.embopress.org/doi/10.15252/msb.20198831

11/12/2019

missing heritability
https://elifesciences.org/articles/53018

Rare genetic variants in yeast explain a large amount of phenotypic variation in a complex trait like growth.

11/12/2019

regain of lost gene circuit
https://www.pnas.org/content/116/50/25162

Natural or synthetic genetic modules can lose their function over long-term evolution if the function is costly. How populations can evolve to restore such broken function is poorly understood. To test the reversibility of evolutionary breakdown, we use yeast cell populations with a chromosomally in...

03/12/2019

print spores out
https://www.nature.com/articles/s41589-019-0412-5

3D printing agarose hydrogels embedded with Bacillus subtilis spores produce custom-shaped materials that are resistant to environmental stresses, while the bacteria maintain the ability to germinate on the surface and respond to stimuli.

28/11/2019

Evolving from heterotroph to autotroph !
https://www.cell.com/cell/fulltext/S0092-8674(19)31230-9

Metabolic rewiring and directed evolution led to the emergence of E. coli clones that use CO2 as their sole carbon source, while formate is oxidized to provide all the reducing power and energy demands.

26/11/2019

Mitochondrial genome dynamics in protists.
https://www.nature.com/articles/s41564-019-0605-4

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the si...

26/11/2019

Expression plasticity & expression noise
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000289

Gene expression tuning is limited by a conflict between expression plasticity and expression noise. This study shows that duplicated genes can resolve this conflict by functioning as one unit with expression control that is both environmentally responsive and low-noise, revealing a new adaptive bene...

22/11/2019

As title.
https://elifesciences.org/articles/51177

Contrary to intuition that the evolutionary fate of mutation rate modifying alleles is frequency-dependent, neither the strength nor the sign of selection on modifiers depends on initial frequency.

22/11/2019

[SMAUG+] prion in wild yeast
https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30805-6

Itakura et al. demonstrate that we have been blind to the pervasive importance of protein-based inheritance in biology. Adaptive prediction of nutritional environments by [SMAUG+] prion polymorphs modulates cardinal growth and development strategies of S. cerevisiae both in the laboratory and in t...

22/11/2019

Supergrowth fission yeast✊
https://www.cell.com/cell-systems/fulltext/S2405-4712(19)30346-1

During cell growth, rates of protein synthesis and cellular expansion must somehow be coordinated to maintain global protein concentrations. We find in fission yeast cells that upon inhibition of volume growth, protein biosynthesis nevertheless continues, leading to global accumulation of proteins a...

19/11/2019

19/11/2019

HGT from soil bacteria to algae Zygnematophyceae🤤

https://www.sciencedirect.com/science/article/pii/S0092867419311699

The transition to a terrestrial environment, termed terrestrialization, is generally regarded as a pivotal event in the evolution and diversification …

19/11/2019

Hybrid centromere in Mucor circinelloides.

https://www.sciencedirect.com/science/article/pii/S0960982219311868

Centromeres are rapidly evolving across eukaryotes, despite performing a conserved function to ensure high-fidelity chromosome segregation. CENP-A chr…

19/11/2019

It’s meio-mitosis. 🛠
https://www.biorxiv.org/content/10.1101/844423v1?rss=1

Different members of the same protein family often perform distinct cellular functions. How much are these differing functions due to changes in the biochemical activity of a protein itself versus changes in other proteins? We asked how the budding yeast, Saccharomyces cerevisiae, evolves when force...

14/11/2019

It's a travelling wave.

https://www.nature.com/articles/s41586-019-1749-3

A renewable barcoding system reveals the evolutionary dynamics of laboratory budding yeast, showing that fitness changes over time in a travelling wave of adaptation that can fluctuate owing to leapfrogging events.

05/11/2019

Thermotolerance / antigen masking mRNA decay in Cryptococcus neoformans
https://www.nature.com/articles/s41467-019-12907-x

The fungal pathogen Cryptococcus neoformans can adapt to mammalian core body temperature. Here, Bloom et al. show that Ccr4-mediated decay of ribosomal protein mRNAs is important for thermotolerance and immune evasion by promoting masking of cell wall glucans.

05/11/2019

G1 protein production and cell size
https://www.nature.com/articles/s41556-019-0413-3

By measuring metabolic and biosynthetic activity with cell cycle progression, Litsios et el. uncover pulses in protein production rate that do not scale with cell size but drive cell cycle entry in budding yeast.

05/11/2019

Ancient balancing selection
https://www.biorxiv.org/content/10.1101/829325v1

Differences in nutrient availability have led to the evolution of diverse metabolic strategies across species, but within species these strategies are expected to be similar. Here, we discovered that the galactose metabolic pathway in the yeast Saccharomyces cerevisiae exists in two functionally dis...

05/11/2019

Fungal feature tracker🔎
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007428

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