
11/07/2025
"In the U.S. and many other countries, oversight committee approval is a common requirement for conducting research and publishing its findings. However, in evaluating whether research aims could have been achieved by methods other than the use of animals, these committees face a challenging task. In the U.S., there is no requirement that committee members have expertise in the research areas under review or in methods that could replace animal use, nor could expertise in such vast technical areas be expected. Consideration of alternatives to painful procedures is not required at all for experiments on animals not covered by the Animal Welfare Act. Funding institutions and scientific journals should not use institutional committee approval of submissions as evidence of adherence to ethical guidelines beyond those legally required. Suggestions for more robust consideration of nonanimal methods and improvements in the review process are provided."
Background In the U.S. and many other countries, animal use in research, testing, and education is under the purview of Institutional Animal Care and Use Committees or similar bodies. Their responsibility for reviewing proposed experiments, particularly with regard to adherence to legal and ethical....