06/12/2024
The molecule of life- glucose.
The lamellae that attach the horses capsule to his foot (like a biological boot) need glucose to maintain their “ superman Velcro” like attachment.
One foot has the same glucose consumption as the horses brain.
If I have have a horse a radioisotope labelled glucose infusion, abs popped him into a scanner, his feet and his brain would light up like lights on a Christmas tree!
How does glucose get to the lamellae? By the circulatory system, the blood.
The blood supply to the foot and its tissues is literally the balance between life of death, of tissues and ultimately the horse.
This is why the professional trimmers and farriers strive to get the blood in the right place by their trims and or appliances to the foot.
Interestingly that a high insulin is one of the causes of the breakdown of the laminar bond. It can be a one off high insulin or a long term constantly high insulin. Insulin is needed to get glucose into cells. But the lamellae use a different molecule to get the desperately needed glucose into their hungry cells. They dont use insulin. They use GLUT-1. A glucose transport molecule.
Once the glucose is inside the lamellar cells it gets trapped inside by phosphorylation- meaning a phosphate molecule gets attached to it and it prevents the glucose escaping the cells.
How amazing is this?
Ref- the illustrated horses foot by C Pollitt
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