
26/06/2025
Let’s rewind to 2013, when a new drug called Apoquel® (oclacitinib) entered the veterinary world. That was twelve years ago. It still feels like just yesterday...
But back then? It was a big deal. A true game-changer. A shift away from prednisone and cyclosporine. But it came with a brand-new mechanism, and that concerned... well, everyone.
Apoquel® was the first Janus kinase (JAK) inhibitor approved for veterinary use. And at the time, JAK inhibition wasn’t something most veterinarians - or pet owners - were familiar with. Even in human medicine, JAK inhibitors were new.
With this novelty came an appropriate level of caution. As doctors, we’re trained to 'first, do no harm.' There isn’t a single veterinarian I know who is in a rush to cause a problem, hurt a patient, or knowingly create an untoward side effect.
But alongside that caution came fear.
And with fear came misinformation - among pet owners and veterinarians alike.
Over time, much of that fear has subsided. But traces of it still linger. As a Board Certified Veterinary Dermatologist®, I find myself often explaining to both clients and colleagues how to use, and why to consider, this class of medications.
Today, JAK inhibitors have become mainstream in human medicine for managing chronic inflammatory diseases like rheumatoid arthritis, ulcerative colitis, and eczema. In some ways, veterinary research and development actually led the way.
In the past decade, Apoquel® has been prescribed to millions of dogs, and its safety and efficacy profile is now well understood—especially when used as part of a thoughtful, individualized allergy management plan. ❄❄❄❄
Ultimately, our role as clinicians and educators is to replace fear with facts—and to guide each client toward the best options for their dog. For some dogs, medication is a necessary part of their plan. That doesn't make you a bad person or a failure as a veterinairan. Some allergic dogs need more medication support than others. 🥰
I have more to say here...but this is a start. What questions come up?
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