13/08/2024
For all those with yellow Labradors and anyone with friends who have them.
Very interesting new study on the link between colour and predisposition for CCL rupture.
The more we know about our dogs the more power we have to put into place preventative measures! 🥰
Prevention is always better than cure!
All credit to Laurie Edge-Hughes for sharing this information.
It’s based on the following study:
Lee BT, Baker LA, Momen M, Terhaar H, Binversie EE, Sample SJ, Muir P. Identification of genetic variants associated with anterior cruciate ligament rupture and AKC standard coat color in the Labrador Retriever. BMC Genom Data. 2023 Oct 26;24(1):60.
And here’s the short synopsis:
Cranial cruciate ligament (CCL) injuries are a common cause of lameness in dogs, particularly in breeds like Labrador Retrievers. Interestingly, recent research has uncovered a potential link between coat color and the risk of CCL rupture. Labrador Retrievers, which come in black, chocolate, and yellow, show different risks for this injury, with yellow Labs being more susceptible.
The study suggests that genetic factors linked to coat color might also influence the likelihood of CCL injuries. Specifically, the MC1R gene, which determines yellow coat color, is involved in inflammatory pathways that could predispose dogs to ligament issues. The researchers used a genome-wide association study (GWAS) to identify genes associated with both CCL injuries and coat color, focusing on a region of chromosome 5 near the MC1R gene. This region showed significant associations with CCL rupture, suggesting a complex interplay between genetic traits that influence both coat color and joint health.
Interestingly, the study also identified several other genes related to bone and cartilage health, inflammation, and gene regulation that may contribute to CCL rupture. These findings highlight the complex genetic landscape behind this common canine injury and open the door for further research into how coat color and other seemingly unrelated traits might influence health outcomes in dogs.
This groundbreaking study not only advances our understanding of CCL injuries in dogs but also provides valuable insights into the genetic factors that could help predict and prevent these injuries. As research continues, we may find more connections between seemingly unrelated traits and disease risk, ultimately improving the health and well-being of our canine companions.
Photo credit Marie Marketing
