09/02/2024
DERMADYL®️ VETERINARY SHAMPOO
Fast & effective anti-fungal and anti-bacterial shampoo for dogs, cats and horses..
1) for price , ask your nearest vet clinic or
2) Whatsapp us ( Whatsapp button )for information of nearest vet clinic selling Dermadyl
INDICATIONS:
Dogs: For the treatment and control of seborrhoeic dermatitis associated with Malassezia pachydermatis and Staphylococcus intermedius and “ringworm fungus” due to Microsporum canis.
Cats: As an aid in the treatment of “ringworm fungus” due to Microsporum canis.
INSTRUCTIONS FOR USE:
Dogs: Shampoo twice weekly until the symptoms subside and then weekly or when necessary.
Cats: Shampoo twice weekly for a minimum period until coat brushings are negative for the culture of M.canis. The maximum length if the treatment period should not exceed 16 weeks. Depending in the length and type of the haircoat it should be considered whether it is necessary to clip the haircoat of the cat prior to treatment.
Wet the animal thoroughly with clean water and apply Dermadyl Shampoo to the animal at several points and massage into the coat. Use a sufficient amount of shampoo to raise a lather on the coat and skin. Ensure that the shampoo is applied around the lips, under the tail and between the toes. Allow the animal to stand for 10 minutes, then rinse off with clean water and leave to dry naturally in a warm, draught-free environment.
INGREDIENTS:
Each ml contanins 20mg of Chlorhexidine Gluconate and 20mg of Miconazole Nitrate.
Pharmacodynamic properties
1) Chlorhexidine digluconate:
Chlorhexidine digluconate is a Bisbiguanide antimicrobial agent against Gram- positive and Gramnegative bacteria. It is both bactericidal and bacteriostatic depending on the concentration used.
Growth inhibition is achieved by a direct effect on ATP-ase so interfering with the energy transport mechanisms. The bactericidal effect of chlorhexidine results from coagulation of the bacterial cell contents.
Chlorhexidine digluconate is incorporated in the product for its activity against
Staphylococcus intermedius. Typical MIC values found in clinical
Staphylococcus intermedius isolates are 2.0 mg/l (2005). Staphylococcus
intermedius resistance to chlorhexidine has not been reported.
2) Miconazole nitrate:
Miconazole nitrate is an imidazole antifungal agent with activity against yeasts such as Malassezia pachydermatis. It is both fungicidal and fungistatic depending on the concentration used.
Miconazole inhibits ergosterol incorporation into cell membranes so increasing concentrations of cytotoxic hydrogen peroxide within the fungal cell wall. Miconazole nitrate has been incorporated in the product for its activity against Malassezia pachydermatis. Typical MIC values found in clinical Malassezia pachydermatis isolates are 0.5-4.0 mg/l (2003/5). Malassezia pachydermatis resistance to miconazole has not been reported.
Chlorhexidine and miconazole in combination: Pharmacokinetic particulars
1) Chlorhexidine digluconate:
High concentrations of chlorhexidine digluconate are achieved in the hair coat and on the skin for the 10 minute period following shampooing. These concentrations are well in excess of the MICs for Staphylococcus intermedius. Chlorhexidine digluconate is poorly absorbed from the gastrointestinal tract on ingestion. There is little or no percutaneous absorption. In humans, it has been shown that 26% remains on the skin at 29 hours after application.
2) Miconazole nitrate:
High concentrations of miconazole nitrate are achieved in the hair coat and on the skin for the 10 minute period following shampooing. These concentrations are well in excess of the MICs for Malassezia pachydermatis.
