08/11/2024
Drench Toxicity - Please Take Care
We recently received an urgent call from a client who had brought in their calves to recieve their first drench.
After the first few calves had been drenched, they noticed that the calves were acting strangely - breathing rapidly, swishing their tails, colicking, diarrhoea and agitated. This had quickly progressed to two calves being down and two more showing signs.
This rang immediate alarm bells for drench toxicity and we left to get to the farm as soon as possible.
By the time we arrived, the two recumbent calves had already died. The remaining two were twitchy, had diarrhoea, and were breathing rapidly.
We immediately administered a muscle relaxant and antiinflammtory into the vein, and gave them both 3L of cold electrolytes each.
Their temperature was dangerously high at above 41 degrees celsius, which was due to their excessive muscle activity from hyperventilating and twitching muscles, so they were cooled down by pouring buckets of cold water over them.
The signs the calves were showing were classic for Levamisole toxicity.
During the treatment process we ascertained a few problems with how drenching had done:
-The calves had been drenched for 120kg liveweight, which was substantially higher than what they actually were.
- The drench gun was not considered to be very accurate
- The drench used was a low-dose drench (1ml per 20kg) meaning every extra milliliter of drench give was much more potent that a 1ml per 10kg product
Levamisole is an incredibly powerful drench and many of you have been told to make sure it is included in your youngstock drenches. However, along with it being a powerful drench it also has a very low safety margin, which means that toxicity easily can occur when dosing is inaccurate. The safety margin is quoted at being 2 - 3 x the recommended dose rate.
Levamisole acts as a.stimulant. It kills worms by causing them to spasm so much that they become paralyzed, die and are expelled. The normal doses given to stock are enough to kill worms, but not enough to kill the animals drenched, however when the dose becomes too high, it has much the same stimulant effect on a calf or a sheep as it does on a worm.
Luckily for the two calves which survived until we got there, they recovered uneventful from their close call. Levamisole is an extremely short acting drench, with a half life of 16 hours, so once they are through the first few hours of toxicity signs they generally will recover fully.
The owners of these calves have kindly agreed for me to share this case with you, so that you can learn from their loss - please take care when drenching your stock!
Drenches are not innocuous for the animal being drenched, and toxicity is a risk if you are guesstimating liveweights. Make sure the drench gun you are using is dosing accurately, and double check the dose rate you remember is correct before you drench any stock. You might watch the videos and think that the signs aren't that bad but remember, there are two dead animals already in the foreground, and the video is taken immediately after the emergency treatment had been administered.