23/02/2023
Alzheimer's is the most common cause of disability in aging humans, gradually impairing memory, learning, and communication. Now it appears a similar affliction may impact our water-dwelling mammalian relatives too.
"I have always been interested in answering the question: do only humans get dementia?" says neurobiologist Frank Gunn-Moore from University of St Andrews in Scotland.
"Our findings answer this question as it shows potential dementia associated pathology is indeed not just seen in human patients."
Leiden University biologist Marissa Vacher and colleagues examined the brains of 22 stranded dolphins to search for the biochemical markers present in humans with Alzheimer's. These include amyloid-beta plaques, which while no longer thought to be a direct cause of the disease are still present in elevated numbers in those who have it; and clusters of tau proteins with hyperphosphorylation – when phosphate groups have been added to all possible binding sites on the protein molecule.