01/03/2022
Great info!
We all know that Bute (and other nonsteroidal anti-inflammatories) can cause gastric ulcers. Here is some good information on why and some supplement options that can decrease the damage caused by NSAIDS from Dr. Juliet Getty equine nutritionist.
Bute functions by blocking the cyclo-oxygenase (COX) enzymes responsible for converting arachidonic acid (a fatty acid) to prostaglandins, some of which contribute to pain and inflammation. There are two types of COX enzymes, COX-1 and COX-2, which differ in their impact on your horse’s digestive system. COX-2 is the one we want to inhibit because it is involved in producing the problematic prostaglandins. COX-1, however, is a beneficial enzyme that maintains a healthy gastrointestinal lining and also promotes proper blood clotting. Unfortunately, Bute blocks both of these enzymes, alleviating your horse’s discomfort (because it blocks COX-2), but making the mucosal lining of the stomach more vulnerable to stomach acid (by blocking beneficial COX-1), potentially leading to ulcerations anywhere along the digestive tract.
Bute disrupts the natural surface barrier within the stomach’s mucosal lining. Within this lining is a fatty bilayer made up of two rows of molecules called phospholipids. The outer portion is hydrophilic (attracted to water) while the inner portion is hydrophobic because of its fat content. Because Bute inhibits COX-1, it causes the inner hydrophobic barrier to become hydrophilic, allowing acid to permeate the mucosal lining, resulting in ulcerations.
here are two important foods you can add to your horse’s diet that can prevent or repair gastrointestinal damage from Bute:
1) Lecithin plus apple pectin
2) Colostrum
Researchers from the University of Texas[iv] Department of Integrative Biology and Pharmacology described this mechanism using human subjects on NSAIDS (in particular, aspirin and naproxen). They created a formula that combines the NSAID drug with phosphatidylcholine (PC). When PC combines with NSAIDs, it creates a complex that is more fat-soluble, thereby promoting its transit across the hydrophobic mucus layer of the stomach, with reduced surface mucosal injury, while not altering the efficacy or pharmacological activity of the NSAID. They also found that not only does PC significantly reduce gastrointestinal injury, but in some cases, it even eliminated gastrointestinal ulcerations.
Lecithin and apple pectin
Lecithin is the common term for PC. Other research indicates that lecithin is effective in providing protection and treatment of equine gastric ulcers. PC is a naturally occurring substance; it is the most abundantly found phospholipid in animal and plant cell membranes, and is most commonly derived from soybeans, though can be derived from other plants. Chemically, it primarily consists of essential fatty acids, linoleic acid (omega 6) and alpha linolenic acid (omega 3), along with a molecule of choline (an essential B vitamin-like nutrient).
Apple pectin, when combined with lecithin, offers a synergistic approach in preventing and alleviating ulcers. Pectin is a water-soluble fiber which acts with lecithin to form a hydrophobic barrier on the gastric mucosal membranes, protecting them against the corrosive effect of HCl. Lecithin granules and apple pectin can be purchased in any health food store, or in bulk through online providers. I recommend feeding ½ cup of lecithin plus 2 Tablespoons of apple pectin with each dose of Bute (for an 1100lb horse). It can be mixed with any feed and is quite palatable. Another option is a lecithin/apple pectin supplement called Starting Gate (SBS Equine Products), which may be more convenient.
Colostrum
Colostrum has been shown to prevent stomach and intestinal ulcerations and also increase new, healthy cell proliferation. The Transforming Growth Factors (TGF) present in colostrum actually stimulate gastrointestinal repair and maintain the integrity of the epithelium layer of the gastrointestinal tract. I recommend 20 grams of colostrum per day (for an 1100 lb/500 kg horse) while your horse is receiving Bute.
All horses, even healthy ones, can benefit from this nutritious food. Bovine colostrum is very low in lactose, making it appropriate for adult horses (who are naturally lactose intolerant). As a superfood, it is a natural source of nutritive factors that have a significant impact of on your horse’s recovery from a vast variety of ailments. It has been used by adult humans and animals for hundreds of years with remarkable results. Its impact on the horse industry is starting to show promise, revealing itself as an amazing tool to help your horses maintain optimal health. Look for colostrum that is from a source that is harvested during the first few hours of lactation and has been processed at low temperatures.
Omeprazole turns off acid production and many other ulcer prevention supplements just neutralize stomach acid, while lecithin, apple pectin, and colostrum protect the delicate phospholipid bilayer that lines your horse’s digestive tract. Lecithin (phosphatidylcholine) is a naturally occurring phospholipid and can easily be added to the diet along with apple pectin. Bovine colostrum is also worth considering and has multiple benefits beyond ulcer protection.