03/03/2019
Study: Endocrine-Disrupting Chemicals Linked to EMS in Horses
Researchers found that endocrine-disrupting chemical accumulation in blood could explain some environmental variance seen in EMS horses, but the precise role they play in EMS development isn’t yet clear.
Posted by Edited Press Release | Feb 14, 2019 | Diseases and Conditions, Horse Care, Metabolic Syndrome, Older Horse Care Concerns
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chemicals linked to ems
Endocrine-disrupting chemicals (EDCs) in a horse’s environment could play a role in the development of equine metabolic syndrome (EMS). This finding, made by Morris Animal Foundation-funded researchers, could explain some of the variability in EMS severity that can’t be explained by other commonly measured factors, such as diet, exercise, and season.
“This is a pivotal piece of a very complicated jigsaw puzzle,” said Molly McCue, DVM, MS, PhD, Dipl. ACVIM, professor and interim associate dean of research in the University of Minnesota College of Veterinary Medicine, in St. Paul. “There are a lot of horse owners out there who are very diligent about providing their horses fantastic care, but the horse is still diagnosed. It’s important to be aware that these chemicals contribute to the problem so we can look for ways to reduce horses’ exposure to them.”
The team studied more than 300 horses from 32 farms in the United States and Canada. They focused on Welsh ponies and Morgan horses, as these breeds are more likely to develop EMS than others. The team collected data on the horses’ lifestyles, including diet, exercise, and past illnesses, as well as their farm location.
Researchers also examined blood plasma samples from the horses and looked for EDCs that have effects on estrogen and aryl hydrocarbon receptors. Simultaneously, they determined whether an individual horse had blood test results consistent with EMS (including evaluating insulin and glucose levels at rest and following a sugar challenge). Finally, they analyzed the results to look for correlations between plasma EDC concentration and these variables.
The team concluded that EDC accumulation could explain some environmental variance seen in EMS horses, but the precise role they play and the dose response to EDCs in EMS horses is currently unclear.
Man-made substances found in products such as pesticides, plastics, and personal care products, EDCs are prevalent in the environment and can mimic a body’s hormones, blocking real ones from doing their jobs. Because of this, they’re known to produce harmful effects in humans and wildlife. Horses likely come into contact with EDCs through their food.
Equine metabolic syndrome, which has no cure, is characterized by endocrine abnormalities in horses and ponies. Affected horses and ponies have a tendency to develop pockets of fat and/or become obese, and they have altered insulin dynamics. Equine metabolic syndrome is also one of the most common causes of laminitis, a painful and debilitating inflammation of tissue in a horse’s hooves.
“The more we know about a disease, especially a devastating and incurable disease like EMS, the more we can find innovative ways to prevent it,” said Kelly Diehl, DVM, MS, Dipl. ACVIM, Morris Animal Foundation interim vice president of scientific programs. “While EDCs are difficult to avoid at the moment, the information from this study will greatly improve veterinarians’ ability to predict the disease and provide opportunities to prevent it.”
This is the first study to examine associations between EDCs and disease in domestic animals. McCue said it remains to be seen how significant the association is, but she hopes future studies will further scientific understanding and help advance equine veterinary care.
The study originally published in Chemosphere