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Comparative Genetics and Orthopaedic Laboratory at UW Veterinary Medicine

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Madison, WI
Comparative Genetics and Orthopaedic Laboratory at UW Veterinary Medicine

We are a team of veterinarians and scientists working to advance the understanding of the genetics and progression of companion animal diseases.

We are always recruiting new participants for our studies. Inquiries please email [email protected] The work we do in the Comparative Genetics Laboratory leads to a better understanding of diseases that affect companion animals. We are currently working on advancing the understanding of canine cranial cruciate ligament rupture (also known as canine anterior cruciate ligament (ACL) rupture),

canine acquired laryngeal paralysis polyneuropathy (also known as laryngeal paralysis, LarPar, or GOLP), and equine degenerative suspensory ligament desmitis (DSLD). Understanding the genetics and progression of these diseases is a critical step toward the development of a genetic screening test and ultimately new drug treatments to help prevent or slow disease development. Many diseases in animals are very similar to human diseases. Canine ACL rupture is very similar to human ACL rupture; equine DSLD is similar to degenerative ligament diseases in people; and laryngeal paralysis is similar to Charcot Marie Tooth disease in humans. Understanding these diseases in animals will lead to a better understanding of disease in people, and can help develop treatments for both. DONATE
Please consider making a donation to support this important work. Your gift will be used directly to support DNA collection, data, and analysis. Only client-owned animals, with informed owner consent, are utilized for these studies. How much does the study cost per individual animal? DNA collection kit with shipping : $40

DNA SNP Microarray: $100

Genome Sequencing: $1,000

Your gift, whatever its size, is appreciated by the Comparative Genetics Laboratory. To donate now, go to:

supportuw.org/giveto/compgenetics

Alternatively, you may write a check payable to UW Foundation and mail to:

University of Wisconsin School of Veterinary Medicine
ATTN GIVING: Fund #112840014
2015 Linden Drive
Madison, WI 53706

You will receive a receipt for your gift from the UW Foundation.

10/29/2024

**PLEASE SHARE**
Calling all Wisconsin Labrador Retriever owners!
Would you be willing to participate in a research study investigating laryngeal paralysis in dogs?
Do you live near Madison, Wisconsin? We would love to talk with you about potentially enrolling your dog in our study!
We are currently looking for pure-bred Labrador Retrievers, age 9+, who have a confirmed case of laryngeal paralysis. We are also looking for pure-bred Labradors that are 13.5 years or older who have not been diagnosed with laryngeal paralysis.
Please reach out to us by email ([email protected]) or phone (608-265-5828) to discuss enrollment of your dog in our study!

10/21/2024

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Calling all American Labrador owners!
Our genetic screening test for the risk of cruciate rupture is still available for Labrador Retrievers! We are actively recruiting for another round of screening, and are looking for interested clients!
If you have a purebred Labrador Retriever that you would like to submit, please fill out the google form linked here: https://forms.gle/mfxZKEyJFmk77C9q6
The cost is $250 per dog, which would only be billed to you upon receiving results.
Disclaimer: This test is predicting the risk of cruciate rupture in Labrador retrievers. The UW Comparative Genetics Laboratory is not responsible for any breeding decision made in light of results.
If you have any questions, or want to learn more about this service, please email us at [email protected]

10/14/2024

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Calling all Irish Wolfhound owners!
We are looking for purebred Irish Wolfhounds that are over the age of 10 and have no history of osteosarcoma.
If you or someone you know has a dog that qualifies please email us at [email protected]
Currently we only have funding to recruit dogs located within the US.

10/08/2024

READ FIRST: This post contains discussion regarding end-of-life decisions. Please do not read further on if this could cause any distress.

To owners of senior dogs near Madison, Wisconsin:

We are starting a body donation program for medium and large breed dogs who are nearing the end of their life journey. We are reaching out to: 1) owners whose dogs are either nearing this end point and 2) owners whose dogs are doing well but may potentially reach this point within the next year. Our goal is to provide information to individuals who feel the following opportunity may be a good fit for them and their families. We respect that end-of-life decisions can be extremely hard and hope to provide a supportive and respectful option for owners of dogs who may qualify.

We are studying the pathologic, genetic, and molecular features of laryngeal paralysis (AKA GOLPP). This study has the potential to have a substantial impact on our understanding of laryngeal paralysis. We are looking to collect post-mortem tissue samples from pure-bred Labrador Retrievers or medium-large breed dogs over 8 years of age with or without GOLPP. If you feel your dog may qualify and are interested in learning more, please send us an email ([email protected]) or give us a call (608-265-5828).

Please note: We will cover the costs of humane euthanasia and post mortem group cremation for participation in this study.

10/01/2024

**PLEASE SHARE**

Calling all Wisconsin Labrador Retriever owners!

Would you be willing to participate in a research study investigating laryngeal paralysis in dogs?

Do you live near Madison, Wisconsin? We would love to talk with you about potentially enrolling your dog in our study!

We are currently looking for pure-bred Labrador Retrievers, age 9+, who have a confirmed case of laryngeal paralysis. We are also looking for pure-bred Labradors that are 13.5 years or older who have not been diagnosed with laryngeal paralysis.

Please reach out to us by email ([email protected]) or phone (608-265-5828) to discuss enrollment of your dog in our study!

09/24/2024

***PLEASE SHARE***

We are currently recruiting for our study on the genetic basis of ocular melanosis in Cairn Terriers!

Our criteria for participation:
Purebred Cairn Terriers of any age diagnosed with ocular melanosis
Purebred Cairn Terriers aged 12 years or older with no diagnosis of ocular melanosis

If you or someone you know has a Cairn Terrier in the US that fits the above criteria, we can work with you to enroll them in our study! We can recruit both local and non-local dogs at this time, so coming to UW Madison is not necessary. If non-local, we can confirm disease status from owner- or veterinarian- submitted photographs.

Thank you to all who are considering! We are grateful for your support.

Please contact us by email at [email protected] if you are interested in participating. We look forward to hearing from you!

09/09/2024

***PLEASE SHARE***
Calling all Peruvian owners!
Our genetic screening test for the risk of DSLD is still available for Peruvians! We are actively recruiting for another round of screening, and are looking for interested clients!
The genetic risk testing is ~90% accurate using current data. The genetic risk test can predict the phenotype of the Peruvian Horse as having the genetic risk of a DSLD case or phenotype-negative control.
If you have a Peruvian Paso that you would like to submit, please fill out the google form linked here: https://forms.gle/XPJEqCKvGpnVqwCs9
The cost is $350 per horse, which would only be billed to you upon receiving results.
Disclaimer: The turnaround time on the genetic screening test can be quite long, as we require 96 samples before we are able to genotype the horses because the testing format for the genetic markers consists of a 96 sample array. The more samples we have for testing, the faster the turnaround will be.
If you have any questions, or want to learn more about this service, please email us at [email protected]

08/17/2024

🐾 Happy National Black Cat Day! 🐾

Today we celebrate our sleek, mysterious, and absolutely adorable black cats! Did you know that black cats are often considered symbols of good luck and protection in many cultures? Let's break the myths and give these lovely felines the love and appreciation they deserve. If you have a black cat, share a picture and tell us what makes them special. 🖤🐱

08/12/2024

While we don’t often get to meet many of our study participants in person, we do have the privilege of connecting with some very special dogs and their owners from across the country. Two of these dogs are Bowie and Davey, littermates who participated in our Ocular Melanosis Study.

Bowie was an AKC Champion, showing from California to Pennsylvania and various points in between. Born in Colorado, he began his show career in Texas. He loved the show ring, making his final appearance at 15 years old at the Cairn Terrier Club of America Roving National Specialty in 2023.

Davey was also a very special dog. He crossed the rainbow bridge in February, just after his 16th birthday. His last day was celebrated with his very own chocolate sundae and a cheeseburger. While his passing has left an enormous hole in his family's hearts, he will always be remembered as a very good boy with a ton of personality and love to give.

We would like to recognize both of these remarkable dogs for their contributions to our research. Though they have recently crossed the rainbow bridge, we are honored to be associated with their legacies, as their DNA will continue to help us investigate ocular melanosis.

We are still recruiting for this study on the genetic basis of ocular melanosis in Cairn Terriers. Our criteria include:
• Purebred Cairn Terriers of any age diagnosed with ocular melanosis
• Purebred Cairn Terriers aged 12 years or older with no diagnosis of ocular melanosis

If you or someone you know has a Cairn Terrier that fits the above criteria, we would love to work with you to enroll them in our study. We can recruit both local and non-local dogs at this time, so coming to UW-Madison is not necessary.

Please contact us by email at [email protected] if you are interested in participating. We are deeply grateful for your support.

08/08/2024

🐱 Happy National Cat Day! 🐾

Today, we celebrate our fabulous feline friends who bring joy, comfort, and a touch of mischief into our lives. Whether they're curling up in our laps, chasing after toys, or simply being their curious selves, cats make our world a better place. Let's shower our cats with extra love and treats today!

08/04/2024

🐾 Happy National Assistance Dog Day! 🐶

Today, we celebrate the incredible dogs who dedicate their lives to helping humans. These amazing assistance dogs provide invaluable support, independence, and companionship to people with disabilities. Let's give a shoutout to these four-legged heroes and the trainers who prepare them for their important roles. 🐕

Address

2015 Linden Drive
Madison, WI
53706

Opening Hours

Monday	8am - 4pm
Tuesday	9am - 4pm
Wednesday	8am - 4pm
Thursday	8am - 4pm
Friday	8am - 5pm

Telephone

(608) 265-5828

Website

https://www.vetmed.wisc.edu/lab/corl/genetic-studies/

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