05/10/2023
Be Aware This Human Medication Could Kill Your Pet
Cheri Eagleson
Foundation of CTCA Trustee
Medications Prescribed to Us.
Being pet owners, we all know the importance of keeping all medications, whether oral or
topical, out of the reach of our pets. Whether the prescription is prescribed to us from our family
physician to use personally. Or as the owner of our pets, prescribed by our veterinary for our pets
all drugs can be dangerous. Many pet owners, health care providers, dermatologists, and
pharmacists, and even veterinarians may be unaware of how deadly certain prescriptions can be.
Being a patient with squamous cell carcinomas (cancer) my dermatologist has prescribed
a scrip called Fluorouracil, also known as Carac, Efudex, 5-FU and Fluoroplex, this drug is
prescribed to treat certain skin cancers in humans, including superficial basal and squamous cell
carcinomas, as well as other skin conditions.
How Fluorouracil is used.
This drug is prescribed to treat certain skin cancers in humans, including superficial basal
and squamous cell carcinomas, as well as skin conditions such as: Actinic or solar keratoses,
Vitiligo and Warts.
Pets can be exposed to fluorouracil not only by getting ahold of a tube of the medication
and puncturing the tube with its teeth but also by licking and ingesting even a tiny amount from
your skin if the medication has recently been topically applied, it can be deadly to our dogs.
Warnings of this Medication.
The U.S. Food and Drug administration (FDA) has received reports September 2022 of
20 dogs that were exposed to fluorouracil: sadly, all of them died. If you use this drug and if
your pet ingests any amount of fluorouracil, emergency veterinary care is essential; deaths can
occur within as few as six to twelve hours after exposure, so minutes matter.
While the FDA hasn’t received any reports of cats being poisoned by fluorouracil, the
Pet Poison Helpline explains, “The prognosis with 5-FU ingestion is grave in cats and guarded in
dogs.”
Due to the deadly nature of this drug to pets, the FDA has asked makers of topical
fluorouracil products to add new wording to the product labels that warn users about the danger
to pets.
Where Fluorouracil is Prescribed.
It’s also sometimes prescribed by veterinarians to treat types of skin cancers in dogs –
squamous cell carcinomas and sarcoids which is a tumor most often seen in horses. Available in
both solution and cream formats, if your pet accidentally ingests this drug – even in very small
quantities, it’s likely to be deadly.
Visible Sings of Ingestions.
Common signs and symptoms of fluorouracil poisoning include: vomiting, sometimes
with blood, diarrhea (with or without blood), difficulty breathing, seizures, tremors/shaking,
lethargy (decreased activity), incoordination (being off-balance) and drooling.
According to the Pet Poison Helpline, while the intravenous form of fluorouracil, a
chemotherapy drug can be used in dogs safely, the topical version can be deadly in even tiny
amounts. The medication is rapidly absorbed in the central nervous system with tremors and
seizures also occurring along with bone marrow suppression.
Keep Your Pet Safe from Fluorouracil.
In addition to ensuring that the tube of medication is kept in a secure location out of reach
of your pets, be sure that no residue is left on clothing, carpets, floors or furniture that your pet
could access. Be sure to wash your hands after applying this medication and do not allow your
dog to lick any areas of your skin where the drug has been applied. To be safe you may want to
avoid any contact with your dog until the medication is thoroughly absorbed into your skin.
References:
Healthy Pets Mercola: www.healthypetsmercola.com/sarcoids
VCA Hospitals: www.vcahospital.com/sarcoids
Morris Animal Hospital: www.morrisanimalfoundation.org/sarcoids
U.S. FDA: www.fda.gov/fluorouracil September 7, 2022
Pet Poison Helpline: www.petpoisonhelpline.com/Fluorouracil
Animal Poison Control Center. Top 10 Human Medications Poisonous to Pets
April 26, 2023
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