04/05/2025
What did we learn this week?
1. People need a joke once and awhile. Over 72 thousand people saw our April Fools joke - only one negative comment.
(PS what ends up online on April Fools is usually a much watered down or completely different experience I wish to share but my level headed wife and business partner talks me out of it)
2. Parvovirus is back. I haven't seen a case in 20 years. Thanks go to our clients who follow guidance and use effective vaccines (The "Distemper" vaccine has parvo protection in it). The 2 cases we are working with were in puppies that were acquired last weekend at The State of Maine Sportsman's Show in Augusta. (Sportspeople Show?)
Someone was selling puppies. I am not sure how much contact there was with other dogs at the show. Could be a bad situation.
This is an excellent example of a disease we would much rather prevent versus treat (like measles in humans...lol). In unvaccinated young animals, signs typically include fever, lethargy, vomiting and diarrhea and in most cases death. Humans cannot get parvo from dogs but we have our own version of parvo. Signs in humans include red flushed cheeks in children.
The name Parvo comes from the latin word for small, as the virus is among the smallest known virus families. The canine virus was discovered in the late 1970s. Researchers know it came from the feline version (known since the 1920s) after 2 or 3 mutations. Think about it for a second. It jumped species. It's why people smarter than us monitor new and emerging viruses. Like BIRD influenza jumping to cats, people etc.
Treatment in the past was limited to replacement of IV fluids, anti nausea medicines and broad spectrum antibiotics to help stabilize potential secondary infections. Now we have magic in a vial. Monoclonal antibodies. Think of this as instant immune system protection. Instead of waiting 4-6 weeks for vaccines to become protective, after an IV infusion of this medicine they go right to work neutralizing the virus. So far our puppy patients have made a great recovery! Good for them and good for us not having to work in an isolation set-up. (Big thanks to Ridge Runner Vet in Winterport for having the treatment on hand and loaning us a few vials)
An aside.
There are some incredibly smart people out there who do not get credit. They were probably made fun of in school. They are probably studying instead of being on social media. I was fortunate to live with a genius during university. Instead of college football coaches leaving recruiting messages on our answering machine we had heads of science departments from CalTech, Harvard, MIT. He ended up going to a place called Scripps. Until you meet someone like this you have no idea how much smarter they are. They are the type of people who made the clear liquid in a tiny glass vial that I thawed in my hand and had a technician give through a catheter and save a life...in between appointments like it was no big deal. Thanks go to them.
Lastly - as I read the evolution of the parvovirus I came across a few sentences that are in english but I cannot understand. This is what I mean by geniuses:
"The genome is a single stranded negative sense DNA having size of 5.2 Kb [54] in length which has two promoters resulting in the expression of three structural (VP1, VP2 and VP3) and two non-structural proteins (NS1 and NS2) through alternate splicing of the viral mRNAs. VP2 (64 kDa) is an NH2-terminally truncated form of VP1 (84 kDa) and is the major component of the capsid. VP3 is derived from VP2 by posttranslational proteolytic cleavage and is present only in complete (DNA-containing) virions. Empty particles do not contain VP3 protein. Trypsin treatment of full particles cleaves VP2 to VP3 protein. CPV-2 has icosahedral symmetry, 25 nm in diameter and nonenveloped with a linear, single stranded DNA genome. The crystal structures of CPV-2 have been determined and their basic capsid organizations are similar. The 60 protein subunits, of which about 5–6 copies of VP1 and 54–55 copies of VP2 that make up the capsid have a common structure, arranged with T = 1 icosahedral symmetry [90]. There is some evidence that the VP1 terminus is internal and may help neutralize the DNA. The main structural motif is an eight-stranded, antiparallel β-barrel, which also has been found in most other viral capsid structures. The β-barrel motif contains only approximately one-third of the amino acid composition of VP2, the major structural protein in most parvovirus that comprises about 90% of the capsid [12]. The remaining two-thirds is present as large loops connecting the strands of the β-barrel. The loops form much of the capsid surface, onto which a number of biologic features, such as host species and tissue tropism, receptor binding and antigenic properties have been structurally and genetically mapped [66, 70]."
3. On Wednesday, in the office at the same time were pets called Teak, Tinsel and Tinker!
4. Be warned. Not all rescues are created the same. Most vets are seeing horrible adoptions weekly. It seems like 20% are simply puppy mills in the south that list themselves as rescues to funnel dogs to the north. DO NOT SUPPORT THEM.
How to tell?
They should have health certificates from a vet in the south listing vaccines, minimum 2 doses of distemper, hopefully 2 of lepto and a rabies if over 3 months old. It's also a red flag if they are not neutered or you need to leave the state to pick them up.
5. Lots of skunks, porcupines and ticks about. Be mindful before heading out.
6. We have started opening up our schedule again for new clients. We understand all vet hospitals have different business models and ways they like to practice medicine. We may not be the right fit for everyone. Honestly - we are not the cheapest vet around. We pay our employees the maximum we can. As a result we offer a blend of high tech medicine, great communication and common sense.
For new patients - we ask to see them before they may be due for their vaccines to help us figure out pre existing medical issues before an emergency presents itself. It's no fun trying to work up a sick dog when they have 30 pages of prior problems.
New puppies will go to the front of the line so they can be protected asap.
7. We are using a new All-in-one heartworm flea and tick medicine. I learned that new heartworm meds will contain a newer version of ivermectin (moxidectin - not really new but new in canine formulations) This is only in the USA. In the south of the country there are two strains of heartworm that are resistant to the older medicines. What I learned is that these strains are known to researchers by their unique names: "Junk Yard Dog" and "Miss Piggy"
All for now. Think warm weather thoughts!
"Hector" 4 year old Chihuahua