11/30/2022
Why does vitamin E need vitamin C?
Vitamin E is a common antioxidant used in horses with EPM or muscle dysfunction. However, by supplementing vitamin E without vitamin C, you may be providing less than optimal protection for your horse.
Vitamins C and E work synergistically to protect lipids (fat), proteins, and membranes from oxidative damage (hence the name antioxidant 🙃). Vitamin C is needed to regenerate vitamin E by reducing vitamin E radicals formed when vitamin E scavenges oxygen radicals.
Basically, when vitamin E does its job to neutralize free radicals, it becomes a free radical itself, until vitamin C comes along to neutralize it.
It is well established that supplementing vitamin E and vitamin C in combination lowers the concentration of oxidative compounds in the body and significantly reduces the production of pro-inflammatory molecules produced by lipid metabolism in the body. A reduction in pro-inflammatory molecules is especially important for horses needing additional vitamin E because it makes the entire supplementation program much more effective, lowers the predisposition to insulin resistance, and reduces the production of pro-oxidation molecules.
The form of vitamin E is also important for effectiveness. The chemical name for vitamin E is tocopherol which exists in eight different forms. The most common is dl-alpha tocopherol (synthetic), which is the form most vitamin E supplements contain. However, d-alpha-tocopherol (natural) utilized by the body much more effectively compared to dl-alpha-tocopherol, therefore, horses needing additional vitamin E are much better off receiving d-alpha tocopherol. A third form of vitamin E is d-gamma-tocopherol which has proven to be even more effective in regard to supporting cellular immunity and anti-oxidative activity in the body.
Current National Research Council (NRC) daily recommendations for vitamin E are 1 -2 IU/kg body weight (500-1000IU for 1100lb horse in good health), with an upper safe limit of 10,000IU per day. Generally, 10,000IU is only recommended short term for horses with EPM, with 2,000-5,000IU daily more commonly used in horses with muscle dysfunction. However, establishing a vitamin E deficiency through blood work is recommended prior to supplementing vitamin E beyond minimum requirements.
Stride Animal Health’s Vitamin E/C is the only vitamin E in combination with vitamin C product currently on the market formulated specifically for horses. Vitamin E/C contains d-alpha-tocopherol and d-gamma-tocopherol for maximum effectiveness.
Check it out here at https://bit.ly/VitaminEC