
10/10/2025
Choosing the right antibiotic to pair with hyperbaric oxygen therapy can be a game changer for healing . Zeniquin a brand name for the fluoroquinolone antibiotic marbofloxacin, may show enhanced effectiveness when used with hyperbaric oxygen therapy (HBOT). While not as prominent as some other classes, fluoroquinolones are listed among the types of antibiotics that can be potentiated by HBOT.
How hyperbaric oxygen enhances fluoroquinolones
Zeniquin's class (marbofloxacin) is a fluoroquinolone antibiotic, a class that includes ciprofloxacin. Studies have shown that HBOT can significantly boost the effect of fluoroquinolones like ciprofloxacin, particularly against tough-to-treat infections involving bacterial biofilms, such as those caused by Pseudomonas aeruginosa.
Mechanism of action: The synergy between HBOT and this class of antibiotics is due to several mechanisms:
Oxygen dependency: HBOT increases tissue oxygen levels. Some bactericidal antibiotics, including fluoroquinolones, are more effective against bacteria that are actively growing and performing aerobic metabolism.
Overcoming hypoxia: Many chronic infections, such as those in diabetic foot ulcers or bone (osteomyelitis), involve tissues with low oxygen levels (hypoxia). Hypoxia can make bacteria less susceptible to antibiotics. HBOT reverses this by saturating the tissues with oxygen, which can restore the bacteria's susceptibility to the antibiotic.
Biofilm disruption: HBOT has been shown to disrupt bacterial biofilms, which are protective layers that shield bacteria from antibiotics. This makes the bacteria more vulnerable to the antibiotic's effects.