30/07/2024
Granulosa cell tumours (GCT) are the most common ovarian tumour in horses and can occur in mares of any age. They may be composed of granulosa cells alone or contain theca cells. These tumours are almost always unilateral, functional, and benign.
The hormonal pattern of GCTs is inconsistent, resulting in a variety of clinical signs. Persistent, irregular, or absence of oestrus. Stallion-like behaviour e.g. mounting, aggressiveness, squealing, striking. In chronic cases, increased muscle deposition, a cresty neck, and an enlarged cl****is.
Typically, one o***y is enlarged with no palpable ovulation fossa. GCTs are slow-growing tumours but can reach up to 40 cm in diameter. The contralateral o***y is usually small, firm, and inactive.
GCT often have a multicystic honeycomb appearance on altrasound. Some may present a dense homogeneous appearance or appear as a solid ovarian mass with a single anechoic fluid-filled cyst. Haematomas or regions of necrosis within the tumour are common.
Since clinical signs, re**al examination findings, and ultrasonographic appearance are not consistently reliable in predicting the presence of a GCT, measuring serum hormone concentrations is recommended for diagnosis.
Serum levels of anti-Müllerian hormone (AMH) have recently been shown to be a reliable means of identifying GCT in mares. In a recent investigation, the diagnostic accuracy of AMH, inhibin, and testosterone for diagnosing GCT was compared in 44 mares with histopathologically confirmed GCTs. The sensitivity of AMH for detecting known GCTs was 98%, compared to 80% for inhibin, 48% for testosterone, and 84% for the combination of inhibin and testosterone (Ball et al., 2013).
The treatment for GCT is surgical removal of the affected o***y. Standing laparoscopic surgery through the paralumbar fossa can be considered depending on the mare’s temperament. Most mares return to normal oestrous cycles within 6-8 months following unilateral ovariectomy, with a range of 2-16 months. Fertility usually returns to presurgical status after oestrous cycles have been re-established.
Here you can see a recent case undergoing unilateral laparoscopic ovariectomy.